نتایج جستجو برای: 293 t با بیان بالای tim3

تعداد نتایج: 1356535  

ژورنال: :مجله دانشکده پزشکی اصفهان 0
مونا مبلغ ناصری دانشجوی کارشناسی ارشد، گروه ژنتیک و زیست شناسی مولکولی، دانشکده ی پزشکی و کمیته ی تحقیقات دانشجویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران حسین خان احمد استادیار، گروه ژنتیک و زیست شناسی مولکولی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران ویدا همایونی دانشجوی دکتری، گروه ایمنی شناسی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران مزدک گنجعلی خانی حاکمی استادیار، گروه ایمنی شناسی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران منصور صالحی استادیار، گروه ژنتیک و زیست شناسی مولکولی، دانشکده ی پزشکی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران ایلناز رحیم منش دانشجوی کارشناسی ارشد، گروه ژنتیک و زیست شناسی مولکولی، دانشکده ی پزشکی و کمیته ی تحقیقات دانشجویی، دانشگاه علوم پزشکی اصفهان، اصفهان، ایران راضیه تقی زاده

مقدمه: گلیکوپروتئین 3tim (3t-cell immunoglobulin and mucin domain) یکی از نشانگرهای سطح سلولی سلول های 1th (1t helper) است که در بسیاری از بیماری های مرتبط با سیستم ایمنی، تغییر بیان دارد. این مطالعه، با هدف بررسی و افزایش بیان پروتئین 3tim در سطح سلول t293 انجام شد. روش ها: کاست بیانی 3tim از روی پلاسمید 67m-2682w-ex با استفاده از پرایمرهای دارای جایگاه آنزیمی nhei و mlui تکثیر و در جایگاه های...

2010
Pushpa Jayaraman Isabel Sada-Ovalle Sarah Beladi Ana C. Anderson Valerie Dardalhon Chie Hotta Vijay K. Kuchroo Samuel M. Behar

T cell immunoglobulin and mucin domain 3 (Tim3) is a negative regulatory molecule that inhibits effector T(H)1-type responses. Such inhibitory signals prevent unintended tissue inflammation, but can be detrimental if they lead to premature T cell exhaustion. Although the role of Tim3 in autoimmunity has been extensively studied, whether Tim3 regulates antimicrobial immunity has not been explore...

Journal: :The Journal of Experimental Medicine 2006
Ken Koguchi David E. Anderson Li Yang Kevin C. O'Connor Vijay K. Kuchroo David A. Hafler

T cell immunoglobulin- and mucin domain-containing molecule (TIM)3 is a T helper cell (Th)1-associated cell surface molecule that regulates Th1 responses and promotes tolerance in mice, but its expression and function in human T cells is unknown. We generated 104 T cell clones from the cerebrospinal fluid (CSF) of six patients with multiple sclerosis (MS) (n = 72) and four control subjects (n =...

2017
Jian‐Feng Liu Si‐Rui Ma Liang Mao Lin‐Lin Bu Guang‐Tao Yu Yi‐Cun Li Cong‐Fa Huang Wei‐Wei Deng Ashok B. Kulkarni Wen‐Feng Zhang Zhi‐Jun Sun

T-cell immunoglobulin mucin 3 (TIM3) contributes to immune suppression during progression of many cancers, but the precise role of TIM3 in head and neck squamous cell carcinoma (HNSCC) is not clearly understood. In this study, we report that TIM3 expression was significantly up-regulated in patients with HNSCC and associated with lymph node metastasis. Additionally, TIM3 expression was increase...

2013
Kaori Sakuishi Shin Foong Ngiow Jenna M. Sullivan Michele W. L. Teng Vijay K. Kuchroo Mark J. Smyth Ana C. Anderson

T-cell immunoglobulin mucin 3 (TIM3) is an inhibitory molecule that has emerged as a key regulator of dysfunctional or exhausted CD8+ T cells arising in chronic diseases such as cancer. In addition to exhausted CD8+ T cells, highly suppressive regulatory T cells (Tregs) represent a significant barrier against the induction of antitumor immunity. We have found that the majority of intratumoral F...

2018
Jian-Feng Liu Lei Wu Lei-Lei Yang Wei-Wei Deng Liang Mao Hao Wu Wen-Feng Zhang Zhi-Jun Sun

BACKGROUND T-cell immunoglobulin mucin 3 (TIM3) is a negative immune checkpoint and plays a crucial part in tumor-induced immune suppression. However, the mechanism of TIM3 in regulating immunosuppression in head and neck squamous cell carcinoma (HNSCC) was still not quite clear. METHODS We carried out the immunohistochemistry staining of HNSCC tissue microarrays. Through quantification of th...

2017
Louis Schofield Lisa J. Ioannidis Stephan Karl Leanne J. Robinson Qiao Y. Tan Daniel P. Poole Inoni Betuela Danika L. Hill Peter M. Siba Diana S. Hansen Ivo Mueller Emily M. Eriksson

BACKGROUND γδ T cells are important for both protective immunity and immunopathogenesis during malaria infection. However, the immunological processes determining beneficial or detrimental effects on disease outcome remain elusive. The aim of this study was to examine expression and regulatory effect of the inhibitory receptor T-cell immunoglobulin domain and mucin domain 3 (TIM3) on γδ T cells...

Journal: :Journal of immunology 2012
Josalyn L Cho Marly I Roche Barry Sandall Abraham L Brass Brian Seed Ramnik J Xavier Benjamin D Medoff

Influenza is a major cause of morbidity and mortality in the United States. Studies have shown that excessive T cell activity can mediate pneumonitis in the setting of influenza infection, and data from the 2009 H1N1 pandemic indicate that critical illness and respiratory failure postinfection were associated with greater infiltration of the lungs with CD8+ T cells. T cell Ig and mucin domain 3...

2011
Shin Foong Ngiow Bianca von Scheidt Hisaya Akiba Hideo Yagita Michele W. L. Teng Mark J. Smyth

Strategies to activate and rescue exhausted tumor-specific T cells, including the use of monoclonal antibodies (mAb) that block the negative costimulatory receptors CTLA-4 and PD-1 are proving very effective, but TIM3 has been relatively neglected as a target. Here we report an extensive characterization of the therapeutic activity and mechanism of action of an anti-mouse TIM3mAb against experi...

2016
Zhu Li Na Li Fang Li Zhihua Zhou Jiao Sang Zhao Jin Huihui Liu Qunying Han Yi Lv Zhengwen Liu

Programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain and mucin domain containing molecule 3 (TIM-3) are involved in hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). This study examined the associations of PD1 and TIM3 polymorphisms with the overall survival (OS) of a prospective cohort of 258 HBV-related HCC patients. Results showed that PD1 +8669 G allel...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید