BACKGROUND ABT-288, a highly selective histamine-3 receptor antagonist, demonstrated efficacy across several preclinical cognitive domains, and safety in healthy subjects and elderly volunteers. OBJECTIVE Evaluate the efficacy and safety of ABT-288 in subjects with mild-to-moderate Alzheimer's dementia. METHODS The study used a randomized, double-blind, placebo- and active-controlled, paral...

Several studies have demonstrated enhanced auditory processing in the blind, suggesting that they compensate their visual impairment in part with greater sensitivity of the other senses. However, several physiological studies show that early visual deprivation can impact negatively on auditory spatial localization. Here we report for the first time severely impaired auditory localization in the...

The consensus of soil fertility specialists working in the northeast USA was that soil testing and recommendation systems for P needed to be reexamined because of recent changes in soil testing methodology in the laboratory and corn (Zea mays L.) production technology in the field. Soil tests (M-COL, MM-COL, B-ICP, M1-ICP, and M3-ICP) were performed by either colorimetry or inductively coupled ...

To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE). This approach makes two major assumptions. First, that the expression of the transporter ...

Collaborative Agreements The degree of authority to write prescriptions delegated to pharmacists varies by state, depending upon the legislation governing pharmacy practice and its interpretation. Generally, however, collaborative agreements allow pharmacists to prescribe and dispense certain drug therapies directly to clients. Currently, 22 states allow pharmacists to prescribe directly or adj...

To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE). This approach makes two major assumptions. First, that the expression of the transporter ...

To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE). This approach makes two major assumptions. First, that the expression of the transporter ...

Anorexia nervosa has the highest mortality rate of any psychiatric condition and its management is complex and multi-faceted, requiring a multidisciplinary team approach. Dietitians are an important part of the multidisciplinary team, offering objective nutritional advice with the aim of helping the patient to develop an improved relationship with food. Refeeding patients with a low body weight...

Fujita Memorial Institute of Pharmacognosy, Fujita Health University, Hisai, Mie 514-1296; Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192; School of Medicine, Fujita Health University, Toyoake, Aichi 470-1192, Correspondence to: Dr. Kan Shimpo, Fujita Memorial Institute of Pharmacognosy, Fujita Health University, Hisai, Mie 514-1296, Japan. Tel: +...