To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE). This approach makes two major assumptions. First, that the expression of the transporter ...

ning services,7 and research has suggested that language barriers, poverty and a maledominated culture are obstacles to the effective practice of contraception.8 These findings imply that Hispanic women would choose to limit their fertility if they had the required knowledge and resources. However, a woman’s intention to have additional children is one of the most important predictors of childb...

Volume 28, Number 6, November/December 1996 volving Church-run institutions. In May 1996, a Catholic health care facility in Troy, New York, agreed, as part of an out-ofcourt settlement, to provide referrals and follow-up for family planning and contraceptive sterilization services. This settlement brought to a close the nation’s first case to challenge the merger of a sectarian and a nonsectar...

To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE). This approach makes two major assumptions. First, that the expression of the transporter ...

To predict transporter-mediated drug disposition using physiologically based pharmacokinetic models, one approach is to measure transport activity and relate it to protein expression levels in cell lines (overexpressing the transporter) and then scale these to via in vitro to in vivo extrapolation (IVIVE). This approach makes two major assumptions. First, that the expression of the transporter ...

Motivation: Establishing phospholipid identities in large lipidomic datasets is a labour-intensive process. Where genomics and proteomics capitalize on sequence-based signatures, glycerophospholipids lack easily definable molecular fingerprints. Carbon chain length, degree of unsaturation, linkage, and polar head group identity must be calculated from mass to charge (m/z) ratios under defined m...

INTRODUCTION The relationship between growth in population and consumption and common-pool resources, particularly those that are governed under common-property institutions, has been the subject of lively academic debate. Researchers have long dwelled upon the global demographic transition and its effect on land-tenure and inheritance practices in different regions of the world. Boserup postul...

We have previously reported that ITR-284, a potent carboxamide-derived anticancer agent, induced apoptosis in leukemia cells. However, there are no reports showing that ITR-284 inhibits human hepatocellular and colorectal cancer cells. In this study, we investigated the antiproliferative effects and apoptotic induction of ITR-284 on various types of human hepatocellular and colorectal cancer ce...