BBR 2778 is a novel aza-anthracenedione with no cardiotoxicity in preclinical models. This Phase I dose escalation trial of BBR 2778 was conducted to determine the maximum tolerated dose, the dose-limiting toxicity, and the pharmacokinetic profile of BBR 2778 in patients with advanced solid tumors. BBR 2778 was given in three consecutive weekly 30-min i.v. infusions over a 4-week cycle (cy). Th...

A technical extension is given for the fixed point statement in Kirk and Saliga [Nonlinear Analysis, 47 (2001), 2765-2778].

Chemical and molecular taxonomic studies were performed on a representative strain of some lactic acid bacteria of unknown taxonomic position isolated from salmonid fish. The results demonstrate that the fish bacterium represents a new species of the genus Lactococcus for which the name Lactococcus piscium sp. nov. is proposed. The type strain of Lactococcus piscium is NCFB 2778.

BACKGROUND A shortage of health professionals in rural areas is a major problem facing China, as more than 60% of the population lives in such areas. Strategies have been developed by the government to improve the recruitment of rural doctors. However, the inequitable distribution of doctors working in China has not improved significantly. The objective of this study was to explore the reasons ...

BACKGROUND AND OBJECTIVES BBR 2778 is a new aza-anthracenedione. Its activity against hematologic neoplasias in a mouse model is greater than that of doxorubicin or mitoxantrone. A phase-I study in patients with non-Hodgkin's lymphoma (NHL) showed that the drug has promising anti-tumor activity. Therefore, a phase-II study in patients with relapsed aggressive NHL was initiated. DESIGN AND MET...

Instant Messaging (IM) is a service defined in RFC 2778 [6] that allows users to send and receive typically short, often textual messages in near real-time. The IETF has defined a generic URI used to identify an IM service for a particular resource: the ’im:’ URI scheme (defined in RFC 3861 [4]). RFC 3861 [4] also defines rules for discovering service running specific protocols, such as SIP (th...

Este estudo descreve o sistema tributário da República Popular China, bem como as medidas tributárias adotadas no combate à crise covid-19, que foram reduções e adiamentos do imposto sobre valor adicionado (IVA) deduções de renda corporativo (Corporate Income Tax – CIT). A China possui um em sua maior parte linha com os padrões internacionais, possuindo uma agência unificada descentralizada par...

If, in some cataclysm, all of scientific knowledge were to be destroyed, and only one sentence passed on to the next generations of creatures, what statement would contain the most information in the fewest words? I believe it is the atomic hypothesis (or the atomic fact, or whatever you wish to call it) that all things are made of atoms—little particles that move around in perpetual motion, at...