نتایج جستجو برای: 25 and 30°c

تعداد نتایج: 16880985  

2016
Fang Peng Jianan He Jacky Fong Chuen Loo Jingyu Yao Lei Shi Chunxiao Liu Chunzhong Zhao Weidong Xie Yonghong Shao Siu Kai Kong Dayong Gu

BACKGROUND Influenza is a serious worldwide disease that captures global attention in the past few years after outbreaks. The recent discoveries of microRNA (miRNA) and its unique expression profile in influenza patients have offered a new method for early influenza diagnosis. The aim of this study was to examine the utility of miRNAs for the diagnosis of influenza. METHODS Thirteen selected ...

2017
J. Zhang J. Ma H. Wang L. Guo J. Li

We aimed to investigate the potential role and mechanism of microRNA-30c (miR-30c) in the pathological development of chronic hepatitis B (CHB). The serum levels of miR-30c in hepatitis B virus (HBV) carrier Xinjiang Uygur patients with inactive, low-replicative, high-replicative and HBe antigen-positive CHB were investigated. HepG2 cells were co-transfected with pHBV1.3 and miR-30c mimic or in...

2014
Xiangyi Kong XiaoFeng Xu Yuhua Yan Feifei Guo Jian Li Yali Hu Huaijun Zhou Qingying Xun

MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour suppressor via the miR-30c-MTA-1 signalling pathway. Furthermore, miR-30c is decreased upon E2 treat...

2015
Qian Zhang Lei Yu Dandan Qin Rui Huang Xiaochen Jiang Chendan Zou Qingchao Tang Yinggang Chen Guiyu Wang Xishan Wang Xu Gao

MicroRNAs (miRNAs) are deregulated in a number of cancers including colorectal cancer. MiR-30c belongs to miR-30 family, and is involved in a variety of malignant diseases. In this study, we detected the expression of miR-30c in colon cancer cell lines and clinical colon cancer specimens. MiR-30c was shown to be dramatically down-regulated both in cell lines and cancer tissues. Additionally, mi...

2017
Xiaoli Chen Yan Jiang Dianling Pan

The present study aimed to investigate the role of miR-30c in endometriosis (EMs) and the underlying mechanism. The expression of miR-30c and plasminogen activator inhibitor type 1 (PAI-1) mRNA in EMs tissues was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and the expression of PAI-1 protein was detected by western blot analysis. The proliferation, migrati...

2016
Zongji Zheng Meiping Guan Yijie Jia Dan Wang Ruoyu Pang Fuping Lv Zhizhou Xiao Ling Wang Hongbin Zhang Yaoming Xue

MicroRNAs (miRNAs) play vital roles in the development of diabetic nephropathy. Here, we compared the protective efficacies of miR-26a and miR-30c in renal tubular epithelial cells (NRK-52E) and determined whether they demonstrated additive effects in the attenuation of renal fibrosis. TGFβ1 suppressed miR-26a and miR-30c expression but up-regulated pro-fibrotic markers in NRK-52E cells, and th...

2017
Yanru Zhao Zhongwei Yin Huaping Li Jiahui Fan Shenglan Yang Chen Chen Dao Wen Wang

Epithelial-to-mesenchymal transition (EMT) plays a significant role in tubulointerstitial fibrosis, which is a hallmark of diabetic nephropathy. Thus, identifying the mechanisms of EMT activation could be meaningful. In this study, loss of miR-30c accompanied with increased EMT was observed in renal tubules of db/db mice and cultured HK2 cells exposed to high glucose. To further explore the rol...

2017
Ya-Qiang Huang Xiao-Hui Ling Run-Qiang Yuan Zhi-Yun Chen Sheng-Bang Yang Hong-Xing Huang Wei-De Zhong Shao-Peng Qiu

Our previous study revealed that microRNA (miR) ‑30c represents a potential tumor suppressor gene, the expression of which is associated with decreased oncogenic potential in prostate cancer (PCa) cell lines. However, the functional role and underlying mechanisms of miR‑30c in PCa remain to be fully elucidated. Reverse transcription‑quantitative polymerase chain reaction and immunohistochemical...

Journal: :International Journal of High Dilution Research 2021

Background and objectives: DNA hyper-methylation is an important aspect involved in carcinogenesis cancer progression, which affects mainly CpG islands of causes inactivation tumour suppressor genes. Therefore hypermethylation status the genomic both transformed cancerous cell lines carcinogen-induced lung was ascertained by analysis expressions certain major specific The other objective to exa...

2015
Ha T. Nguyen Wei Jia Aaron M. Beedle Eileen J. Kennedy Mandi M. Murph Chunhong Yan

Although microRNAs (miRNAs) are small, non-protein-coding entities, they have important roles in post-transcriptional regulation of most of the human genome. These small entities generate fine-tuning adjustments in the expression of mRNA, which can mildly or massively affect the abundance of proteins. Previously, we found that the expression of miR-30c-2-3p is induced by lysophosphatidic acid a...

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