p53 protects cells from genetic assaults by triggering cell-cycle arrest and apoptosis. Inactivation of p53 pathway is found in the vast majority of human cancers often due to somatic missense mutations in TP53 or to an excessive degradation of the protein. Accordingly, reactivation of p53 appears as a quite promising pharmacological approach and, effectively, several attempts have been made in...

Over the past two centuries human life expectancy has increased by nearly 50 years. Genetic factors account for about one-third of the variation in life expectancy so that most of the interindividual variation in lifespan is explained by stochastic and environmental factors, including diet. In some model organisms, dietary (energy) restriction is a potent, and highly reproducible, means of incr...

PRIMA-1met (APR-246) is a methylated derivative and structural analog of PRIMA-1 (p53 re-activation and induction of massive apoptosis). PRIMA-1met has been reported to restore both the wild type (wt) structure and function of mutant p53. Here, we show that PRIMA-1met is highly effective at limiting the growth of CRC cells regardless of p53 status. However, PRIMA-1met induces robust apoptosis o...

Based on discrete event-triggered communication scheme (DETCS), this paper is concerned with the satisfactory H ! / H 2 event-triggered fault-tolerant control problem for networked control system (NCS) with α -safety degree and actuator saturation constraint from the perspective of improving satisfaction of fault-tolerant control and saving network resource. Firstly, the closed-loop NCS model w...

ST-246, a novel compound that inhibits egress of orthopoxvirus from infected cells, is being evaluated as a treatment for pathogenic orthopoxvirus infections in humans. This phase I, double-blind, randomized, placebo-controlled, escalating multiple-dose study was conducted to determine the safety, tolerability, and pharmacokinetics of ST-246 administered as a single daily oral dose of 250, 400,...

Family Planning Perspectives Unintended pregnancies occur all too commonly in the United States. Although their impact on individual women or couples varies, such pregnancies have been linked to a number of social and health problems, such as poor birth outcomes.1 However, despite the frequency and the consequences of unintended pregnancy, its definition—and therefore its measurement—remains el...

Family Planning Perspectives pared with 63% of those among Hispanic women and 54% of those among white and other non-Hispanic women.2 The greater prevalence of unplanned pregnancy among low-income women and among black or Hispanic women reflects their lower levels of contraceptive use3 and higher likelihood of contraceptive failure.4 However, it is not clear whether racial and ethnic difference...

Erythrocytes and plasma proteins contribrelated (p < 0.001) with the plasma ute to viscosity of blood. Therefore, blood macroglobulin concentration in g/100 ml. viscosity was measured in 16 persons with The plasma of patients with macroglobumacroglobulinemia with a cone-plate vislinemia is a non-Newtonian fluid, but at a cometer at defined shear rates. In each given shear rate the plasma viscos...