Ceramide kinase (CerK) produces the bioactive lipid ceramide-1-phosphate (C1P) and appears as a key enzyme for controlling ceramide levels. In this study, we discovered and characterized adamantane-1-carboxylic acid (2-benzoylamino-benzothiazol-6-yl)amide (NVP-231), a potent, specific, and reversible CerK inhibitor that competitively inhibits binding of ceramide to CerK. NVP-231 is active in th...

A disproportionate share of temporary help agency employees consists of young, female, predominantly minority workers, many of them recent or current welfare recipients. In 2001, for example, nearly 60 percent of temporary services workers were women, half of them between the ages of 16 and 34. And whereas the proportion of black and Hispanic workers in traditional employment—around 11 percent—...

conceptualization (AC) mode,230, 231; accommodators, 231; activeexperimentation (AE) mode, 230, 231;assimilators, 231, 232; concreteexperience (CE) mode, 230, 231;convergers, 231, 232; derived learningstyles, 231; divergers, 231; learningcycle, 230–231; reflective observation(RO) mode, 230, 231Krathwohl, D. R. See Anderson andKrathwohl’s hybrid taxonomy<l...

Breast cancer metastasizes to bone, visceral organs, and/or brain depending on the subtype, which may involve activation of a host organ-specific signaling network in metastatic cells. To test this possibility, we determined gene expression patterns in MDA-MB-231 cells and its mammary fat pad tumor (TMD-231), lung-metastasis (LMD-231), bone-metastasis (BMD-231), adrenal-metastasis (ADMD-231) an...

The goal of this contribution is to share our experience in organizing and participating to the "ICT4SD: Information and Communication Technologies for Sustainable Development" [1] doctorate course. The course was held at the International Graduate School on Information and Communication Technology (ICT) [2] of the University of Trento (Italy) during the 2005/2006 academic year and it was promo...

The primate visual system is broadly organized into two segregated processing pathways, a ventral stream for object vision and a dorsal stream for space vision. Here, evidence from functional brain imaging in humans demonstrates that object representations are not confined to the ventral pathway, but can also be found in several areas along the dorsal pathway. In both streams, areas at intermed...

We give a method based on an idea of O. Veblen which gives explicit formulas for the covariant derivatives of natural objects in terms of the Christooel symbols of a symmetric Ehresmann "-connection.