Development of a vaccine against congenital infection with human cytomegalovirus is complicated by the issue of re-infection, with subsequent vertical transmission, in women with pre-conception immunity to the virus. The study of experimental therapeutic prevention of re-infection would ideally be undertaken in a small animal model, such as the guinea pig cytomegalovirus (GPCMV) model, prior to...

The sequence of a newly discovered isolate of guinea pig cytomegalovirus (GPCMV), the CIDMTR strain, was determined. The 232,778-nucleotide genome was generally well conserved with that of the 22122 reference strain, although some regions of substantial sequence divergence allowed annotation of strain-specific open reading frames encoding putative immune modulation gene products.

OBJECTIVE To describe the behavior of mortality in Mexico through four indicators from 1990 to 2012. MATERIAL AND METHODS The official mortality and population records of Mexico were used. RESULTS An advance was achieved for children under five years of age, with a decrease in mortality, although there was an increase in the years of potential life lost (YPLL) from 2008 for this age group. ...

INTRODUCTION Quantifying years of potential life lost (YPLL) highlights childhood causes of mortality and provides a simple method to identify important causes of premature death. METHODS CDC analyzed data from the National Vital Statistics System multiple cause of death files for 2000-2009. RESULTS An average of 890YPLL were lost each year due to unintentional injuries for every 100,000 pe...

In the light of Mozambique's progress towards the achievement of Millennium Development Goal 4 of reducing mortality of children aged less than five years (under-five mortality) by two-thirds within 2015, this study investigated the relationship between the province of mother's residence and under-five mortality in Mozambique, using data from the 2003 Mozambican Demographic and Health Survey. T...

This study defined a wealth index that was strongly correlated with a health indicator: the survival of children aged less than five years. This index allowed the most vulnerable social groups for health outcomes to be identified. These groups could become the target for focused interventions and in particular for health-insurance schemes. The study was based on a thorough analysis of data coll...

BACKGROUND Growth failure in children less than five years old can lead to the serious complications such as increased mortality, learning difficulties or physical disability. The aim of this study was to investigate the nonorganic factors affecting the growth trend in less than two years children living in Zanjan, Iran. METHODS This longitudinal study was conducted on a sample of 3566 childr...

As primary caregiver to under-five children in Ethiopia, mothers' knowledge, perception, and management skills are important to minimize the effects of morbidity and mortality associated with diarrhoeal diseases. A community-based comparative cross-sectional study was conducted in Abramo and Megele 37 kebeles (the last administration division) in Assosa district of western Ethiopia in July 2010...