Generation of neurons from patient fibroblasts using a combination of developmentally defined transcription factors has great potential in disease modelling, as well as ultimately for use in regeneration and repair. However, generation of physiologically mature neurons in vitro remains problematic. Here we demonstrate the cell-cycle-dependent phosphorylation of a key reprogramming transcription...

This paper explores the relationship between special-interest groups and volatility of GDP growth. In an unbalanced panel of 108 countries, we find a significant negative relationship between the number of interest groups in a country and the volatility of GDP growth. Citation: Coates, Dennis, Jac Heckelman, and Bonnie Wilson, (2007) "Special-Interest Groups and Volatility." Economics Bulletin,...

Kevin D. O'Brien, David M. Shavelle, Michael T. Caulfield, Thomas O. McDonald, Katherine Valvular Lesions and in Human Plasma Association of Angiotensin-Converting Enzyme With Low-Density Lipoprotein in Aortic Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue...

We present the results of precision timing observations of the binary millisecond pulsar PSR J1640+2224. Combining the pulse arrival time measurements made with the Effelsberg 100-m radio telescope and the Arecibo 305-m radio telescope, we have extended the existing timing model of the pulsar to search for a presence of the effect of a general-relativistic Shapiro delay in the data. At the curr...

Backache with its many causes continues to present a challenge to the examining physician. Careful history taking, inspection and palpation still have an essential role, as well as the most modern imaging techniques. Although extra-pulmonary tuberculosis (TB) has shown a disproportionate increase in recent years, muscular TB is still uncommon. Necropsies of 2224 TB cases revealed only four with...

OBJECTIVE To evaluate the relationship between frequency of pruritic symptoms experienced over a 1-month period and psychological stress. DESIGN Cohort study. SETTING Population-based study in Japan. PARTICIPANTS A total of 2224 participants at least 18 years old and without psychiatric disorders participated in the Japan Health Diary Study (October 2003), a cohort study comprising a repr...

OBJECTIVES The Japanese Liver Transplantation Society is a cooperative research consortium, established in 1980 to characterize and follow trends in patient and graft survival in all liver transplants in Japan. This study evaluated the effect of graft size matching on survival in pediatric recipients of living donor liver transplant. MATERIALS AND METHODS Between November 1989 and December 20...