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Timed up and go test and risk of falls in older adults: a systematic review. Beauchet O, Fantino B, Allali G, Muir SW, Montero-Odasso M, Annweiler C. J. Nutr. Health Aging 2011; 15(10): 933-938. Of the 92 selected studies, 11 met the selection criteria and were included in the final analysis. Fall rate ranged from 7.5 to 60.0% in the selected studies. The cut-off time separating non-fallers and...

BACKGROUND Targeted alpha therapy has been postulated to have great potential for the treatment of small clusters of tumour cells as well as small metastases. (213)Bismuth, an α-emitter with a half-life of 46 min, has shown to be effective in preclinical as well as in clinical applications. In this study, we evaluated whether (213)Bi-[DOTA(0), Tyr(3)]-octreotate ((213)Bi-DOTATATE), a (213)Bi-la...

1.—Institute for Microelectronics, Technical University of Vienna, 1040 Vienna, Austria. 2.—School of Engineering, University of Warwick, Coventry CV4 7AL, UK. 3.—Department of Aircraft Technology, Technological Educational Institution of Sterea Ellada, 34 400 Psachna, Greece. 4.—Department of Microelectronics, IAMPPNM, NCSR ‘Demokritos’, 153 10 Athens, Greece. 5.—Department of Physics, Compute...

Recurrent prostate cancer presents a challenge to conventional treatment, particularly so to address micrometastatic and small-volume disease. Use of α-radionuclide therapy is considered as a highly effective treatment in such applications due to the shorter range and exquisite cytotoxicity of α-particles as compared with β-particles. (213)Bi is considered an α-emitter with high clinical potent...

PURPOSE Ovarian peritoneal carcinomatosis is a pathology for which effective cures are currently lacking. New research protocols seek to eradicate residual micrometastases following cytoreductive surgery by using hyperthermic intraperitoneal chemotherapy (HIPEC) or radioimmunotherapy (RIT). This study aims to first develop alpha-RIT using an anti-CD138 mAb radiolabeled with an alpha-emitter, bi...

Saquinavir (SQV) is a protease inhibitor widely used for the treatment of human immunodeficiency virus (HIV) infection. We profiled SQV metabolism in mice using a metabolomic approach. Thirty SQV metabolites were identified in mouse feces and urine, of which 20 are novel. Most metabolites observed in mice were recapitulated in human liver microsomes. Among these novel metabolites, one a-hydroxy...

The effect of rifampicin on the pharmacokinetics of fexofenadine enantiomers was examined in healthy subjects who received fexofenadine alone or with single or multiple doses of rifampicin (600 mg). A single coadministered dose of rifampicin significantly decreased the oral clearance (CLtot/F) and renal clearance (CLr) of Sand R-fexofenadine by 76 and 62%, and 73 and 62%, respectively. Even aft...