The actin-nucleation-promoting factor cortactin has emerged not only as a crucial regulator of actin cytoskeletal dynamics, but also as a key player in aggressive cancers (Buday and Downward, 2007; Weaver, 2008). Cortactin was first identified as a prominent substrate of the Src nonreceptor tyrosine kinase. Its name was derived from the observation that cortactin localizes to cortical actin str...

Nightlight Christian Adoptions [3] et al. v. Thompson et al. was a lawsuit filed in the United States District Court for the District of Columbia on 8 March 2001. The suit was filed because Nightlight Christian Adoptions [3], a frozen embryo [4] adoption agency, felt that the Guidelines for Research Using Human Pluripotent Stem Cells [5] published by the National Institutes for Health were unla...

Thomson [4], et al. v. Thompson, et al. was a lawsuit filed in the United States District Court for the District of Columbia on 8 May 2001 as Civil Action Number 01-CV-0973. This lawsuit was filed in hopes of gaining injunctive relief against a moratorium on the federal funding of stem cell research. The plaintiffs in the case were seven prominent scientists who performed embryonic stem cell re...

Climate change is affecting the tourism industry through many different mechanisms (Weaver 2011;Gössling, 2002, 2007; Berrittella et al. 2005; Hall and Higham 2005; Peeters 2005; Dubois and Ceron 2006; Becken and Hay 2007; Buckley 2008; UNWTO-UNEP-WMO 2008;Gössling et al. 2009). These include: environmental changes and human responses at tourist destinations and countries of origin (Koenig and ...

Considerable interest has recently focused on the weaver mutation, which causes inward rectifier channel alterations leading to profound impairment of neuronal differentiation and to severe motor dysfunction in mice (Hess, 1996). The principal targets of mutation are cerebellar granule cells, most of which fail to differentiate and degenerate in a premigratory position (Rakic and Sidman, 1973a,...

The weaver mutation impairs migration of the cerebellar granular neurons and induces neuronal death during the first two weeks of postnatal life. To elucidate the molecular mechanisms for the impaired neuronal migration, we investigated the rescue mechanisms of the weaver (wv/wv) granule neurons in vitro. We found that Fab2 fragments of antibodies against a neurite outgrowth domain of the B2 ch...