Cefazolin injection (3000 mg/kg, i.v.) in mice showed several behavioral excitations such as wild running, jumping, rolling, and finally undergoing severe convulsions followed by death. It's lower doses (500-2000 mg/kg, i.v.) were unable to produce any convulsions or behavioral excitations in mice. However, cefazolin (500 or 1000 mg/kg, i.v.) when administered before different doses of pentylen...

progressive usage of medicinal plants has necessitated their mass production using the minimum amounts of chemical inputs. to find out the effects of urea and pelleted animal manure and some micronutrients on yield and its components in pumpkin, a split plot experiment based on rcbd with three replicates was conducted at the research farm of abouraihan campus, university of tehran in 2011. the ...

BACKGROUND Clusters of sudden unexplained death (SUD) in Yunnan Province, China, have been linked to eating Trogia venenata mushrooms. We evaluated the toxic effect of this mushroom on mice. METHODS We prepared extracts of fresh T. venenata and Laccaria vinaceoavellanea mushrooms collected from the environs of a village that had SUD. We randomly allocated mice into treatment groups and admini...

Coriandrum sativum L. (CS) seeds are known to possess therapeutic potentials against a variety of physiological disorders. This study assesses acute and sub-chronic toxicity profile of hydro-methanolic extract of CS seeds using OECD guidelines. In acute toxicity study, mice were once orally administered 1000, 3000 and 5000 mg/kg body weight of CS extract. There were no any behavioral alteration...

pumpkin is one the most important cultivated medicinal plants. because of high quality oil it uses as edible and herbal medicine. to find out the effects of different rates of pelleted animal manure and urea levels and some micronutrients on morphophysiological characteristics and oil yield of medicinal pumpkin, a split plot experiment based on rcbd with three replicates was conducted at the re...

It is presumed that drugs sourced from herbs have lesser side effects than allopathic drugs. Enantia chlorantha is widely used in herbal medicine for the treatment of several ailments such as jaundice, malaria, fever, infective hepatitis, etc. However its toxicity profiles are not well documented. The effects of ethanolic extract of E. chlorantha stem bark on body weight changes, biochemical an...

This study evaluated the safety of rambutan rind extract (RRE) in male Wistar rats. While acute toxicity was evaluated by feeding the rats with single doses of RRE (1000, 2000, 3000, 4000, and 5000 mg/kg) and its sub-chronic toxicity was observed in rats orally administered with RRE (500, 1000, and 2000 mg/kg) daily for 30 days. In acute toxicity study, the LD50 was found to be greater than 500...

Objective: This study determined the toxicity and toxicokinetics of polydatin when administered via oral gavage to Sprague Dawley rats daily for 4 weeks. Background: Polydatin continues to be investigated as a potential therapy for a variety of human diseases. Methods: Male and female Crl:CD(SD) rats were assigned to five groups, and different doses (0, 300, 600, 1200, or 3000 mg/kg/day) of pol...

Abstract Background The present study focused on the antidiabetic potential and fingerprinting analysis of Bryophyllumc pinnatum stems as well its possible mechanisms action along with identification major phytoconstituents. oral glucose tolerance test has been performed administering a solution (2000 mg/kg) to induce hyperglycemia. Diabetes have instigated by single intra-peritoneal injection ...