The North American river otter (Lontra canadensis) is a biomonitor for organohalogenated compounds (OHCs) associated with a wide range of deleterious health effects in wildlife and humans. We determined concentrations of twenty OHCs in livers of 23 river otters salvaged by the Illinois Department of Natural Resources from 2009 to 2011, determined sex-dependent distribution of OHCs, and compared...

Since its development, tariquidar (TQR; XR9576; N-[2-[[4-[2-(6,7Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]4,5-dimethoxyphenyl]quinoline-3-carboxamide) has been widely regarded as one of the more potent inhibitors of P-glycoprotein (P-gp), an efflux transporter of the ATP-binding cassette (ABC) transporter family. A third-generation inhibitor, TQR exhibits high affinity fo...

Completing everyday tasks often requires the execution of action sequences matched to a particular problem. To study the neural processes underlying these behaviors, we trained monkeys to produce a series of eye movements according to a sequence that changed unpredictably from one block of trials to the next. We then applied a decoding algorithm to estimate which sequence was being represented ...

Eleven mild atopic asthmatic patients were exposed for 6 h, in randomized order, to air, 100 ppb O3, 200 ppb NO2, and 100 ppb O3 + 200 ppb NO2, followed immediately by bronchial allergen challenge. Subsequently 10 of these patients were exposed for 3 h to air, 200 ppb O3, 400 ppb NO2, and 200 ppb O3 + 400 ppb NO2, followed immediately by bronchial allergen challenge. All exposures were carried ...

Table 1. Chemical composition of the Martian atmosphere. Spacecraft data are in black, ground-based spectroscopy is in red, spectroscopy from Earthorbiting observatories in blue. Species Mixing ratio Instrument CO2 0.955 GS N2 0.027 Viking/MS Ar 0.016 Viking/MS Ne 2.5 ppm Viking/MS Kr 0.3 ppm Viking/MS Xe 80 ppb Viking/MS H 2.7×10 cm Mariner/UVS O 0.01-0.02 Mariner/UVS O2 (1.2−2)×10 FPI CO 8×10...

Quantification of particulate (w0.45 mm) and dissolved (v0.45 mm) trace elements in seawater is imperative for understanding geochemical cycling in the marine environment. Suspended particulate trace element concentrations are typically v10% of total element concentrations in seawater. To overcome analytical difficulties associated with low analyte concentrations, it is common to filter large v...

We wanted to determine whether the production of endogenous nitric oxide (NO) is affected by cigarette smoking and various pathological conditions. Endogenously produced NO was measured by chemiluminescence in the exhaled air of 81 healthy volunteers (21 nonsmoking females (NSF), 12 smoking females (SF), 24 nonsmoking males (NSM) and 24 smoking males (SM)) and 38 patients (10 with hypertension,...

The transcription factor p63 (Trp63) plays a key role in homeostasis and regeneration of the skin. The p63 gene is transcribed from dual promoters, generating TAp63 isoforms with growth suppressive functions and dominant-negative ΔNp63 isoforms with opposing properties. p63 also encodes multiple carboxy (C)-terminal variants. Although mutations of C-terminal variants have been linked to the pat...