This study investigated the metabolism of salvianolic acid A (SAA) both in vivo and in vitro. Liquid chromatography–mass spectrometry analysis of drug-containing rat bile samples and bile samples hydrolyzed by glucuronidase revealed a series of methylated conjugates of SAA and its glucuronides, as well as the predominance of the methylation pathway of SAA in rats. For the first time, four major...

Volume 28, Number 6, November/December 1996 volving Church-run institutions. In May 1996, a Catholic health care facility in Troy, New York, agreed, as part of an out-ofcourt settlement, to provide referrals and follow-up for family planning and contraceptive sterilization services. This settlement brought to a close the nation’s first case to challenge the merger of a sectarian and a nonsectar...

Diverse morphological tooth deformities are found in various shapes, textures, and prevalence. They can be sporadic or syndromes, nutritional, environmental, genetic, and ethnic related. Most of these tooth-born (ie, patient born with the deformation) deformations (eg, shovel-shaped incisors, tuberculum Carabelli, variations in number and shape of cusps, dens invaginatus, taurodontism) have bee...

Interactions between the soma and germline are essential for gametogenesis. In the Drosophila testis, differentiating germ cells are encapsulated by two somatic cells that surround the germline throughout spermatogenesis. chickadee (chic), the fly ortholog of Profilin, mediates soma-germline interactions. Knockdown of Chic in the soma results in sterility and severely disrupted spermatogenesis ...

to require abortion providers to notify parents of abortions performed on minors, to impose restrictions on Medicaid funding for abortion and to create 24-hour waiting periods. An unintended effect of such restrictions may be an accelerated growth in nonmarital births that, in turn, increases the proportion of unmarried women heading families. Our study addresses a straightforward question with...

Anorexia nervosa has the highest mortality rate of any psychiatric condition and its management is complex and multi-faceted, requiring a multidisciplinary team approach. Dietitians are an important part of the multidisciplinary team, offering objective nutritional advice with the aim of helping the patient to develop an improved relationship with food. Refeeding patients with a low body weight...

We present a microfluidic approach for single-molecule studies of the temperature-dependent behavior of biomolecules, using a platform that combines microfluidic sample handling, on-chip temperature control, and total internal reflection fluorescence (TIRF) microscopy of surface-immobilized biomolecules. With efficient, rapid, and uniform heating by microheaters and in situ temperature measurem...

This study determined whether the orientation of dorsoplantar and oblique foot radiographs has an effect on radiograph interpretation. A test set of 50 consecutive foot radiographs were selected (25 with fractures, and 25 normal), and duplicated in the horizontal orientation. The images were randomly arranged, numbered 1 through 100, and analysed by six image interpreters. Vertical and horizont...

widely used to generate coherent light at frequencies at which laser light is unavailable. Standard devices can have a very high efficiency (close to 100%), but they employ pure, sizeable — and hence expensive — nonlinear single crystals, and require careful adjustments. On page 374 of this issue, Baudrier-Raybaut et al. show that efficient optical frequency conversion can be achieved in disord...

A mechanism of buoyancy regulation in cyanobacteria was investigated in a fluctuating light environment typical of the mixed layer in a lake. New measurements of density and cellular carbohydrate content were obtained from a field sample of the cyanobacterium Microcystis aeruginosa. The rate of increase in carbohydrate and density in this cyanobacterium does not instantaneously adjust to an inc...