Previous studies have demonstrated that nucleic acid polymers (NAPs) have both entry and post-entry inhibitory activity against duck hepatitis B virus (DHBV) infection. The inhibitory activity exhibited by NAPs prevented DHBV infection of primary duck hepatocytes in vitro and protected ducks from DHBV infection in vivo and did not result from direct activation of the immune response. In the cur...

Understanding drug-drug interactions (DDIs) is a key component of clinical practice ensuring patient safety and efficacy of medicines. The role of drug metabolites in DDIs is a developing area of science, and has been recently highlighted in a draft regulatory guidance. The guidance states that metabolites representing ‡25% of the parent drug’s area under the plasma concentration/time curve and...

0022-1694/$ see front matter Crown Copyright 2 http://dx.doi.org/10.1016/j.jhydrol.2013.02.046 ⇑ Corresponding author. Tel.: +61 293855140; fax: E-mail addresses: [email protected] (R. edu.au (A. Sharma), [email protected] (D. Nage iisc.ernet.in (T.V. Reshmidevi). Impact of global warming on daily rainfall is examined using atmospheric variables from five General Circulation Mod...

Impact assessment of climate change on potato productivity in Punjab for three potato cultivars of late (Kufri Badshah), medium (Kufri Jyoti) and early (Kufri Pukhraj) maturity groups was carried out for A1FI scenario of temperature and atmospheric CO2 of the years 2020 and 2055. The simulation study was done using WOFOST crop growth model for potential production at 13 locations in Punjab. The...

Nucleic acid polymers (NAPs) block the release of subviral particles from hepatocytes, a mechanism consistent with their antiviral activity against hepatitis B virus (HBV) in patients. Analysis of immunostimulatory properties of NAPs were conducted with several NAP species: REP 2006, the prototypic degenerate NAP [dN]40, containing TLR9-stimulatory CpG; REP 2055 a clinically active NAP with a s...

Objective: The study evaluated the prevalence and progression of different thyroid tumors in patients who referred to Shahid Sadoughi Hospital during 2005 to 2013, Yazd, Iran. Materials and Methods: In this retrospective follow-up study, cytopathological data of patients suffering from thyroid masses was collected during 2005-2013. Age and sex of patients were recorded. Results: Totally, 2055...