نتایج جستجو برای: 2α
تعداد نتایج: 2439 فیلتر نتایج به سال:
چکیده زمینه و هدف: سرطان تیروئید شایعترین بدخیمی غدد درون ریز میباشد. به دلیل ناهمگونی بالای ندولهای توموری و غیرتوموری تیروئید از نظر ویژگیهای آسیب شناسی و فقدان مارکرهای مولکولی مناسب، تلاشهای گستردهای برای معرفی یک مارکر مولکولی جهت تشخیص این ضایعات توموری در حال انجام است. Survivinعضو جدیدی از خانوادهی پروتئینهای مهارکننده مرگ برنامهریزی شده سلولی می باشد که در بررسی های اخیر بر...
In this paper we prove, if θ∈C([0,∞),H2−2α(R2)) is a global solution of supercritical surface Quasi-Geostrophic equation with small initial data, then ‖θ(t)‖H2−2α decays to zero as time goes infinity. Fourier analysis and standard techniques are used.
The transcription factor hypoxia-inducible 2α (HIF-2α) is a key oncogenic driver in clear cell renal carcinoma (ccRCC). HIF-2α protein levels are tightly regulated post-translationally an oxygen-dependent manner. Hypoxic conditions or aberrations the Von-Hippel Lindau (VHL) ubiquitin ligase complex lead to stabilization and of various pro-tumorigenic gene sets. Clinical evidence indicates that ...
Objective This study aimed to investigate the effects of hypoxia-inducible factor-1α (HIF-1α), factor-2α (HIF-2α), and erythroferrone (ERFE) on hepcidin in patients with chronic kidney disease (CKD) stages 3–5 renal anemia. Methods A total 90 CKD anemia were selected for at Nephrology Department Fujian Provincial People’s Hospital divided into three groups, according stage, while another 30 hea...
Objective: To identify the prognostic significance of CD147 and HIF-2α expressions in localized clear cell renal cell carcinoma (ccRCC). Methods: Tissue microarrays of 74 cases of ccRCC without distant metastasis or invasion were performed by CD147 and HIF-2α immunohistochemical staining. The expressions were qualified by intensity and percentage of tumor cells stained. Results: Increased expre...
Transcription factor activator protein 2α (AP-2α) is a negative regulator of adipogenesis by repressing the transcription of CCAAT/enhancer binding protein (C/EBPα) gene. During adipogenesis, AP-2α is degraded, leading to transcriptional up-regulation of C/EBPα. However, the mechanism for AP-2α degradation is not clear. Here, using immunoprecipitation assay and mass spectrometry, we identified ...
Activating enhancer-binding protein-2α (AP-2α) regulates the expression of many cancer-related genes. Here, we demonstrated a novel mechanism by which AP-2α up-regulated cyclooxygenase-2 (COX-2) expression to promote the growth of nasopharyngeal carcinomas (NPCs). High expression of AP-2α in NPC cell lines and tumor tissues from NPC patients was detected and significantly correlated with COX-2 ...
Constitutive functional HIF-2α was recently identified in cancer and stem cell lines under normoxia. In this study, BEAS-2B, a bronchial epithelial cell line, was shown to constitutively express active HIF-2α under normoxia and exhibit markers of pluripotency including Oct-4, Nanog, and sphere formation. Oct-4 expression was reduced after knockdown of HIF-2α under normoxia. Global enrichment an...
Sleep-disordered breathing with recurrent apnea produces chronic intermittent hypoxia (IH). We previously reported that IH leads to down-regulation of HIF-2α protein via a calpain-dependent signaling pathway resulting in oxidative stress. In the present study, we delineated the signaling pathways associated with calpain-dependent HIF-2α degradation in cell cultures and rats subjected to chronic...
In soft tissue sarcomas (STS), low intratumoural O2 (hypoxia) is a poor prognostic indicator. HIF-1α mediates key transcriptional responses to hypoxia, and promotes STS metastasis; however, the role of the related HIF-2α protein is unknown. Surprisingly, here we show that HIF-2α inhibits high-grade STS cell growth in vivo, as loss of HIF-2α promotes sarcoma proliferation and increases calcium a...
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