Diaminopyridine dendritic scaffolds encapsulate polymeric flavin via non-covalent interactions and demonstrate isolation of the redox moiety.

Parasympathetic withdrawal plays an important role in the autonomic dysfunctions in hypertension. Since hyperpolarizing, voltage-sensitive K(+) channels (K V) hamper transmitter release, elevated K V-activity may explain the disturbed vagal control of heart rate (HR) in hypertension. Here, the K V inhibitor 3,4-diaminopyridine was used to demonstrate the impact of K V on autonomic HR control. C...

The regular arrangement of complementary diaminopyridine-thymine (DAP-THY) on alternating copolymers permits cooperative binding events and the effective formation of well-controlled micrometre-scale aggregates.

Pyridines fused with heterocyclic rings are of great interest as both photovoltaic materials and biologically active compounds. The most convenient precursors for these compounds pyridine-2,3-diamines. In this communication, 3,4-diaminopyridine-2,5-dicarbonitrile was synthesized by the reaction 2,5-dibromo-3,4-diaminopyridine copper cyanide; best yield target compound achieved heating mixture i...

4-Aminopyridine and 3,4-diaminopyridine were evaluated for their abilities to delay the onset of paralysis due to botulinum neurotoxin types A, B, and E. Experiments were done on phrenic nerve-hemidiaphragm preparations excised from mice. At a concentration that produced an enhancement in muscle twitch amplitude, 4-aminopyridine and 3,4-diaminopyridine delayed the onset of paralysis due to botu...

2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. Consequently, they aren't...

Diaminopyridine are important class of organic compounds, mostly used for synthesis of dyes, cosmetics, drugs and explosives. Recently, 2, 4-diaminopyridine was used as pharmacological agent for muscle relaxant used in anesthesia and it can increase the neuromuscular transmission in certain disease conditions. Additionally, 3, 4-diaminopyridine was used as a drug for the treatment of Lambert– E...

Multi-functional nanoparticles possessing magnetic, fluorescence and transition metal ion response properties were prepared and characterized. The particles have a core/shell structure that consists of silica-coated magnetic Fe₃O₄ and 2,6-diaminopyridine anchored on the silica surface via organic linker molecules. The resultant nanoparticles were found by transmission electron microscopy to be ...

New highly nucleophilic homogeneous and heterogeneous catalysts based on the 3,4-diaminopyridine scaffold are reported for halogen-free cycloaddition of CO2 to epoxides.

An effective and direct synthetic strategy for a new series of functionalized mono-, bis-, spiro[1,2,4]triazolo[1,5-a]pyridines from 1,2-diaminopyridine precursor has been described. Reaction o...