The development, application, and advantages of a one-flask multicomponent dithiane linchpin coupling protocol, over the more conventional stepwise addition of dithiane anions to electrophiles leading to the rapid, efficient, and stereocontrolled assembly of highly functionalized intermediates for complex molecule synthesis, are described. Competent electrophiles include terminal epoxides, epic...

About 20 years have elapsed since those studies were done. During this period, many changes that might influence teenage reproductive behavior and how it is viewed have taken place within the industrialized world. The proportion of births to unmarried women has risen,2 and nonmarital childbearing is more acceptable, both among adolescents and among women older than 20. Access to contraception a...

Addition of lithiated alkyl dithianes to benzoyl chloride or methyl benzoate does not produce the expected product of double addition, alpha,alpha-bis(alkyldithianyl) benzyl alcohol, for alkyls larger than methyl. Instead, the first step intermediate, i.e. 2-benzoylated dithiane, undergoes an electron-transfer reduction by the second molecule of the dithianyl anion. This reduction is followed b...

In the title compound, C(13)H(15)NO(2)S(2), the nitro group is coplanar with the benzene ring to which it is attached, forming a dihedral angle of 1.07 (14)°. The dithiane ring adopts a chair conformation. In the crystal structure, mol-ecules are linked through C-H⋯O and C-H⋯π [C⋯Cg = 3.7164 (15) Å] inter-actions. The crystal studied was an inversion twin with an 0.134 (5):0.866 (5) domain ratio.

Use of a bis-dithiane deprotection-tandem bis-spiroacetalisation sequence was key to the successful synthesis of the [5,6,6]-bis-spiroacetal of the antimitotic agent spirastrellolide B, achieved in a highly convergent fashion involving successive dithiane alkylations.

The reaction of antimony(III) chloride with 1,4-dithiane (1,4-dt) in the ionic liquid [BMIM]Cl ([BMIM]Cl: 1-butyl-4-methylimidazolium chloride) with an excess of the Lewis acid AlCl3 results in the formation of a ligand-stabilized stibenium cation [SbCl2]. 1,4-Dithiane simultaneously serves as a chelating η2-ligand, exhibiting a boat-like conformation, as well as a bridging μ2-ligand, exhibitin...

The title compound, C(11)H(13)NO(2)S(2), contains a 1,3-dithiane ring in an almost ideal chair conformation with the following puckering parameters: Q = 0.7252 (15) Å, θ = 6.71 (13) and ϕ = 50.4 (11)°. The benzene ring occupies an axial position at the dithiane ring. The nitro group is almost coplanar with the benzene ring [O-N-C-C = -3.2 (2)°]. The mol-ecule has an L-shape with a C-C-C-C torsi...

Maoecrystal V is a highly oxidized and rearranged norterpenoid isolated from the Chinese herb, Isodon eriocalyx. A synthetic route for C/D/E-ring core compound of maoecrystal has been developed. Introduction C1 fragment to D/E-ring was achieved by lithito dithiane attack, C-ring formed deprotective intramolecular hemiacetalization dithiane-alcohol precursor.

[reaction: see text]. Synthesis of novel dithiane-spiro-crown ethers starting from 5,5-di(hydroxymethyl)-1,3-dithiane is developed. These compounds can be used as building blocks to assemble photolabile bis-crown ethers via addition to dicarbonyl-containing tethers, e.g., isophthalic aldehyde. It is found that unlike their mono-crown precursors such bidentate bis-crowns are capable of efficient...