In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro anti-inflammatory activity of various 1-[5-(substituted phenyl)-1-phenyl-4,5dihydro-1H-pyrazol-3-yl]-5-phenyl-1H-tetrazole (IV a-h).The anti-inflammatory activity of title compounds were examined by denaturation of proteins method. All the compounds exhibited weak to potent anti-inflammatory act...

Novel scaffolds are of uttermost importance for the discovery of functional material. Three different heterocyclic scaffolds easily accessible from isocyanoacetaldehyde dimethylacetal 1 by multicomponent reaction (MCR) are described. They can be efficiently synthesized by a Ugi tetrazole multicomponent reaction of 1. We discuss the synthesis, 3D structures, and other physicochemical properties.

The coordination of 2-pyridyltetrazolate and ortho-xylene-linked bis(NHC)cyclophane to Pt(II) yielded a novel complex characterised by enhanced pure deep-blue emission, whose intensity can be modulated via methylation of the tetrazole ring.

An improved method of the synthesis of flavanones catalyzed by pyrrolidine and BF(3) ·Et(2) O has been developed and a lot of flavanones could be easily synthesized via this method. The asymmetric synthesis of flavanone from benzaldehyde and 5-fluoro-2-hydroxyacetophenone has been studied and flavanone with moderate enantioselectivity was obtained in one step.

The title compound, C(7)H(13)N(5), a tetrazole analogue of betaines, exists as a zwitterion, with the H atom of the tetrazole ring being transferred to the piperidine ring N atom. The tetrazole ring symmetry is close to C(2v), which suggests strong charge delocalization in the N-C-N fragment of the ring. There are classical hydrogen bonds in the structure which are responsible for the formation...

An adaptive tetrazole-derived host provides insight into tetrazolate-biomolecule interactions, and is the first member of a new family of receptors that function in pure water.

The metal-organic framework [Cd15(5MT)18(OH)4(SO4)4] (5-MT = 5-methyl-1H-tetrazole) with an unprecedented Cd(3)(micro3-OH)(micro3-SO4) core and two kinds of tetrazole coordination modes was formed by self-assembly and in situ synthesis of the 5-MT tetrazole ligand; the structure exhibits an unusual 3(9) x 4(12) x 5(15) topological network and shows reversible shrinkage and expansion in a crysta...

We have isolated the stable as well as the metastable tautomers of 1-deazapurine in the solid state by exploiting principles of supramolecular selectivity in the context of cocrystal design.