نتایج جستجو برای: 1beta (il

تعداد نتایج: 141377  

Journal: :iranian journal of allergy, asthma and immunology 0
katarina stavric university children hospital skopje, republic of macedonia sonja peova university children hospital skopje, republic of macedonia dejan trajkov institute of immunobiology and human genetics, faculty of medicine, university "ss cyril and methodius", skopje, republic of macedonia mirko spiroski institute of immunobiology and human genetics, faculty of medicine, university "ss cyril and methodius", skopje, republic of macedonia

atopic dermatitis (ad) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of t-helper 2 cells. the aim if this study was to determine whether cytokine gene polymorphisms might influence the development of ad. single nucleotide polymorphisms in the genes for i-l1alpha, il-1beta, il-1r, il-2, il-4, il-6, il-10, il-12, tgf beta, tnf and ifng...

Journal: :iranian journal of allergy, asthma and immunology 0
mojgan ghaedi department of immunology, school of public health, tehran university of medical sciences, tehran, iran hayedeh namdari department of immunology, school of medicine, shiraz university of medical sciences, shiraz, iran parisa rahimzadeh department of immunology, school of public health, tehran university of medical sciences, tehran, iran sahar morteza gholi department of immunology, tabriz university of medical sciences, international campus (aras), jolfa, tabriz, iran maryam azimi mohamadabadi department of immunology, school of medicine, tehran university of medical sciences, tehran, iran eisa salehi department of immunology, school of medicine, tehran university of medical sciences, tehran, iran

an appropriate differentiation of distinct human cd4+ t cell subset is critical for manipulating these cells for using in immunity related diseases. despite various attempts to clarify the role of different factors involved in th17 differentiation, many crucial contradictions yet remained to be optimized. although it has been shown that the differentiation of in-vitro th17 cells culture conditi...

Journal: :The Journal of clinical endocrinology and metabolism 2001
H Y Huang Y Wen J S Kruessel F Raga Y K Soong M L Polan

The interleukin (IL)-1 system is a major regulator of local cellular interactions during embryonic implantation. Because IL-1beta and IL receptor antagonist (IL-1ra) are both expressed in human endometrium, we hypothesized that an appropriate ratio of IL-1beta to IL-1ra might favor the process of embryo implantation. Therefore, we investigated IL-1 regulation of the quantitative ratio of IL-1be...

Journal: :Blood 2000
S Gardella C Andrei S Costigliolo L Olcese M R Zocchi A Rubartelli

The role of interleukin-1beta (IL-1beta) as a regulator of the immune response, although extensively investigated, is still debated. We then studied the expression of IL-1beta by human dendritic cells (DCs), the professional antigen presenting cells, and its modulation during immune reactions in vitro. Our results show that, on maturation or tetanus toxoid presentation to specific CD4(+) CD40L(...

Journal: :Neoplasia 2001
M S Maliner-Stratton R D Klein T S Udayakumar R B Nagle G T Bowden

Previously, our laboratory showed that interleukin-1beta (IL-1beta) secreted by lipopolysaccharide-activated monocytes induces promatrilysin expression in the prostate carcinoma cell line, LNCaP. We now demonstrate that IL-1beta-induced promatrilysin expression is mediated by an indirect mechanism that requires nuclear factor Kappa B (NFkappaB)-dependent synthesis of IL-6. Inhibition of protein...

2009
Helen J. Lachmann Philip Lowe Sandra Daniela Felix Christiane Rordorf Kieron Leslie Sheril Madhoo Helmut Wittkowski Stephan Bek Nicole Hartmann Sophie Bosset Philip N. Hawkins Thomas Jung

The investigation of interleukin 1beta (IL-1beta) in human inflammatory diseases is hampered by the fact that it is virtually undetectable in human plasma. We demonstrate that by administering the anti-human IL-1beta antibody canakinumab (ACZ885) to humans, the resulting formation of IL-1beta-antibody complexes allowed the detection of in vivo-produced IL-1beta. A two-compartment mathematical m...

2005
Che Wang Min-wei Wang Shin-ichi Tashiro Satoshi Onodera Takashi Ikejima

Interleukin-1beta (IL-1beta) is a pivotal proinflammatory cytokine. To investigate the mechanism of IL-1beta-induced cell death in human malignant melanoma A375-S2 cells, MTT assay, photomicroscopical observation, DNA agarose gel electrophoresis, radioimmunoassay and Western blot analysis were carried out. IL-1beta did not only induce nuclear condensation and DNA fragmentation, but also increas...

Journal: :Acta neurobiologiae experimentalis 2013
Ewa Badowska-Szalewska Beata Ludkiewicz Justyna Sidor-Kaczmarek Grazyna Lietzau Jan H Spodnik Dariusz Świetlik Beata Domaradzka-Pytel Janusz Moryś

It is postulated that stress differentially affects interleukin-1beta (IL-1beta) during ontogenetic life. This study examined the influence of chronic exposure to forced swim (FS) stress or high-light open-field (HL-OF) stress on interleukin-1beta (IL-1beta). The total level of IL-1beta protein was assessed by Western blot analysis of hippocampal extracts. Double immunofluorescence staining was...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999
A J Puren G Fantuzzi C A Dinarello

Interleukin (IL)-18, formerly called interferon gamma (IFN-gamma)-inducing factor, is biologically and structurally related to IL-1beta. A comparison of gene expression, synthesis, and processing of IL-18 with that of IL-1beta was made in human peripheral blood mononuclear cells (PBMCs) and in human whole blood. Similar to IL-1beta, the precursor for IL-18 requires processing by caspase 1. In P...

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