Cornelia Isabella Bargmann studied the relationship between genes [4], neural circuits, and behavior in the roundworm Caenorhabditis elegans [5] (C. elegans) during the twentieth and twenty-first centuries in the US. Bargmann?s research focused on how the sense of smell (olfaction) in the nematode word Caenorhabditis elegans [6]. She provided a model to study how neural circuits develop and fun...

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Germline mutations in PTPN11, encoding Shp2, cause Noonan syndrome (NS) and LEOPARD syndrome (LS), two developmental disorders that are characterized by multiple overlapping symptoms. Interestingly, Shp2 catalytic activity is enhanced by NSmutations and reduced by LS mutations. Defective cardiac development is a prominent symptom of both NS and LS, but how the Shp2 variants affect cardiac devel...

Disinhibition is a cardinal feature of the behavioural variant of frontotemporal dementia, presenting as impulsive and impetuous behaviours that are often difficult to manage. The options for symptomatic treatments are limited, but a potential target for therapy is the restoration of serotonergic function, which is both deficient in behavioural variant frontotemporal dementia and closely associ...

Low-doped silicon multi-nanowire field effect transistors with high ON/OFF ratio over 10 and a low subthreshold swing of 60–120 mV dec 1 are fabricated using lithographic semiconductor processes. The use of multi-nanowires instead of a single nanowire as sensing elements has shown improved device uniformity and stability in buffer solutions. The device stability is further improved with surface...

Data relating to the incidence of anencephalus for the 12-year period 1961-72 were abstracted from the Statistical Reviews of the Registrar General for Scotland. It was shown that considerable geographical variation is still apparent with the highlands having, in general, the lower incidences. In comparison with the earlier study of Edwards (1958), there were some changes: the incidence in the ...

This study examines the trends in air temperature, precipitation and flow rates over a 50-year observation period (1961–2010) compares two periods, 1961–1985 1986–2010. The research was carried out terms of annual monthly values. area is Hornad River Slovakia. main aim to examine evolution precipitation, temperature flows catchment area, as well identify regions (sub-catchments) most vulnerable...