With the recent interest on the theranostic approach, there has been a renewed interest for alternative radionuclides in nuclear medicine. They can be produced using common production routes, i.e., using protons accelerated by biomedical cyclotrons or neutrons produced in research reactors. However, in some cases, it can be more valuable to use deuterons as projectiles. In the case of Cu-64, sm...

DIABETES IS AN INDEPENDENT RISK FACTOR FOR THE DEVELOPMENT OF CARDIOVASCULAR DISEASE (CVD),1,2 AND A GROWING BODY OF EVIDENCE SUGGESTS THAT sleep-disordered breathing (SDB) is associated with adverse CVD risk factors and outcomes, including hypertension and myocardial infarction.1-5 The prevalence of hypertension, atherosclerotic CVD, and myocardial infarction are elevated in individuals with d...

Development, homeostasis and regeneration of tissues result from a complex combination of genetics and mechanics, and progresses in the former have been quicker than in the latter. Measurements of in situ forces and stresses appear to be increasingly important to delineate the role of mechanics in development. We review here several emerging techniques: contact manipulation, manipulation using ...

The axon initial segment (AIS) is a specialized region in neurons where action potentials are initiated. It is commonly assumed that this process requires a high density of voltage-gated sodium (Na1) channels. Paradoxically, the results of patch-clamp studies suggest that the Na1 channel density at the AIS is similar to that at the soma and proximal dendrites. Here we provide data obtained by a...

The immune and neuroendocrine systems of invertebrates, as well as vertebrates, share a common pool of molecules that have been conserved throughout evolution. Now we add a new interface to this bidirectional interaction, demonstrating the involvement of the gut system, showing that these three systems use the same biologically active peptides.

Rhemium-186-1-hydroxyethylidene-1,1-diphosphonate ((186)Re-HEDP) has been used for the palliation of metastatic bone pain. However, delayed blood clearance and high gastric uptake of radioactivity have been observed upon injection, due to the instability of (186)Re-HEDP. We designed, synthesized and evaluated a stable (186)Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosph...

OBJECTIVE Rhenium is one of the most valuable elements for internal radiotherapy because (186)Re and (188)Re have favorable physical characteristics. However, there are problems when proteins such as antibodies are used as carriers of (186/188)Re. Labeling methods that use bifunctional chelating agents such as MAG3 require the conjugation of the (186/188)Re complex to protein after radiolabelin...