However, the popularity of the method, which was initially very high, has declined precipitously.8 Sales of the device fell from 800 per day in the first quarter of 1994 to about 60 per day in April 1995; the U. S. distributor speculated that “adverse publicity and negative word-of-mouth” drove the decline.9 While both the IUD and oral contraceptives have suffered declines in use attributed to ...

Impairment of drug disposition in the liver during inflammation has been attributed to downregulation of gene expression of drugmetabolizing enzymes (DMEs) and drug transporters. Inflammatory responses in the liver are primarily mediated by Toll-like receptors (TLRs). We have recently shown that activation of TLR2 or TLR4 by lipoteichoic acid (LTA) and lipopolysaccharide (LPS), respectively, le...

A recent decision by several Australian State politicians to support a parliamentary review of artificial water fluoridation has an intensified debate on the public health intervention. While there is a majority agreement among Australian dentists and other health professionals that adequate enamel fluoride is essential for dental health, the ethics of artificial fluoridation of public water su...

for Disease Control and Prevention (CDC) to measure high-priority health-risk behaviors among adolescents at the national, state and local levels.6 We address three questions in this article: What were the trends in sexual behavior among U.S. high school students during the early 1990s? How does sexual behavior vary by race and ethnicity, and how have these differences changed over time? And fi...

In this article, we present recent neuroimaging studies performed to identify the neuralnetwork involved in handwriting. These studies, carried out in adults and in children, suggestthat the mastery of handwriting is based on the involvement of a network of brain structureswhose involvement and inter-connection are specific to writing alphabet characters. Thisnetwork is built up...

It is estimated that by 2050 there will be 2 billion people aged 60 years and older in the world. The evidence base for the health benefits of good nutrition and physical activity, as well as weight loss among overweight and obese adults, is growing and a number of policies and guidelines are available to guide health professionals in serving older people at various stages of the lifecycle. The...

Understanding climate change and its potential impact on species, populations and communities is one of the most pressing questions of twenty-fi rst-century conservation planning. Palaeobiogeographers working on Cenozoic fossil records and other lines of evidence are producing important insights into the naturally dynamic nature of climate and the equally dynamic response of species, population...

Vol. 1, No. 4 ■ May 2001 U ntil quite recently, the seizure disorders of childhood were broadly associated with generalized disruptions in brain maturation and, by association, the complete range of behavioral and intellectual deficits common in children with epilepsy. This concept of pediatric epilepsy as a cause of diffuse cognitive problems was supported by several lines of evidence as well ...