Phosphatidylserine (PS) externalization is a marker for the nucleated cell apoptosis, and refers cellular activation rather than apoptosis in platelets. On the other hand, several similarities exist between platelet activation and apoptosis in nucleated cells. Herewith we investigated the relationship between platelet activation and platelet apoptosis. Platelets isolated from fresh blood of 22 ...

“The hardest thing about [the textbook] is pronouncing the names of its authors.” The course website is http://math.stanford.edu/~schoen/math171/. This is a course in mathematical analysis, so in addition to the content of the course, the class also emphasizes the art of writing proofs, and thus we will be nickled-and-dimed in our proofs. Additionally, this is a Writing in the Major course, so ...

Toxinotype of Clostridium perfringens (CP) isolates collected from the Bernam River, Selangor River and Tengi Canal between April 2007 and January 2008 were determined by Polymerase Chain Reaction (PCR) using published primers. All the 147 isolates were toxinotype Type A, harbouring the alpha toxin gene. In addition, 5 of the isolates also had the enterotoxin (CPE) gene. Clostridium perfringens...

Idiosyncratic hepatotoxicity has been associated with the oral tyrosine kinase inhibitor lapatinib, which is used in metastatic breast cancer therapy. Lapatinib is extensively metabolized by cytochrome P450 3A4/5 to yield an O-debenzylated metabolite, which can undergo further oxidation to a reactive quinone imine. A recent clinical study reported that concomitant use of lapatinib with dexameth...

Fluorescence resonance energy transfer (FRET) from cyan to yellow fluorescent proteins (CFP/YFP) is a well-established method to monitor protein-protein interactions or conformational changes of individual proteins. But protein functions can be perturbed by fusion of large tags such as CFP and YFP. Here we use G protein–coupled receptor (GPCR) activation in living cells as a model system to com...

The behavior of SFE-171 used for food fortification was studied. The biological and nutritional properties of this new iron source are discussed in this work.

Phillipa Caudwell, Catherine Gibbons, Mark Hopkins, Erik Naslund, Neil King, Graham Finlayson and John Blundell* Institute of Psychological Sciences, Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, UK Sport, Health, Leisure and Nutrition, Leeds Trinity University College, Brownberrie Lane, Horsforth, Leeds LS18 5HD, UK Clinical Sciences (Division of Surgery), Danderyd Hospit...

1 Department of Psychology, Queens College, City University of New York, Flushing, NY 11367, USA 2 The Graduate Centre, City University of New York, New York, NY 10016, USA 3 Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA 4 State Key Laboratory of Cognitive Neuroscience and Learning and International Data Group/McGovern Institute for Brain Research, B...