Due to the drawbacks of applying catalysts in the synthesis of α,β-unsaturated structure units and the importance of these materials, electrochemistry has been introduced as an efficient alternative.Therefore, herein a high-yield synthesis of 2-arylideneindan-1,3-diones is proposed. The procedure is carried out in propanol, using electrons as a green catalyst for generating propanol anion...

Background: Lead (Pb) is classified as a major risk factor affecting the male reproductive system; however, itsprecise mechanisms of action are poorly understood and inconsistent. This work aimed to investigate effect ofPb toxicity on function.Methods: Accordingly, in this study, adult mice treated with acetate (PbAc) by gavage (200 mg/kg/day) for 28 days. We analyzed sperm count morphology, ox...

This study was to investigate the effect of annexin A5 on testosterone secretion from primary rat Leydig cells and the underlying mechanisms. Isolated rat Leydig cells were treated with annexin A5. Testosterone production was detected by chemiluminescence assay. The protein and mRNA of Steroidogenic acute regulatory (StAR), P450scc, 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β-hydroxysteroid d...

Hydroxysteroid dehydrogenases (HSDHs) are from two superfamilies of short-chain dehydrogenase (SDR) and aldo–keto reductase (AKR). The HSDHs were summarized classified according to their structural functional differences. A typical pair enzymes, 7α–hydroxysteroid (7α–HSDH) 7β–hydroxysteroid (7β–HSDH), have been reported before. Molecular docking 7-keto–lithocholic acid(7–KLA) the binary 7β–HSDH...

Rhodococcus equi ATCC13557 was selected as a model organism to study oestrogen degradation based on its previous ability degrade 17α-ethinylestradiol (EE2). Biodegradation experiments revealed that R. unable metabolise EE2. However, it able E2 with the major metabolite being E1 no further of E1. conversion into incomplete, 11.2 and 50.6% degraded in mixed (E1-E2-EE2) E2-only conditions, respect...

C-Ring oxidized estrone acetate derivatives as antiproliferative agents were prepared and tested against five cancer cell lines by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Flow cytometry assays to evaluate viability modifications in cycle phases molecular docking research estrogen receptor α, steroid sulfatase, 17β-hydroxysteroid dehydrogenase type 1 performed. 9α...

Bisphenol A (BPA) is a potential endocrine disruptor. It has been shown that it reduces serum testosterone level in rodents after exposure. However, the mechanism is unclear. The object of the present study is to investigate the effects of BPA on human and rat steroidogenic enzymes including P450 17α-hydroxylase/17,20-lyase (CYP17A1), 3β-hydroxysteroid dehydrogenase (3β-HSD) and 17β-hydroxyster...