Circulating lipoproteins may offer interesting properties as therapeutic carriers for cytokines and hormones, in terms of both stability and bio-distribution. The fusion of apolipoprotein A-I with interleukin-15 (IL-15) targets the latter to high-density lipoproteins (HDLs). The bioactivity of this chimera can be further enhanced by creating triple fusions with IL-15 receptor α domain involved ...

One artifact from my childhood in the 1960’s that I still remember vividly is the series of plastic slidingblock puzzles manufactured by The Roalex Company of Forest Hills, NY (no relation to the maker of fine timepieces). These consisted of a high-quality plastic puzzle glued to a piece of cardboard containing information about the puzzle. Most of their sixty or so different designs were based...

We show that the mixing time for the fifteen puzzle in an n× n torus is on the order of n logn.

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In the course of our chemical screening program for novel metabolites by LC-MS monitoring, we isolated a new aspochracin derivative, JBIR-15 (1), together with aspochracin, from the culture broth of a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04. The structure of 1 was determined to be N-demethyl aspochracin at the alanyl residue on the basis of extensive NMR and MS analyses.

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I was very honored to receive the University of California, San Francisco, and the International Society of Pharmacometrics Lewis Sheiner lecturer award in May 2013. In the present perspective, I outline the main points of my lecture at the American Conference of Pharmacometrics (slides in Supplementary Material 1). I first emphasize the scientific contributions of Lewis Sheiner as a quantitati...

8-puzzle is typically solved by heuristic search. Real-time heuristic search usually gives better results when searching deeper. But sometimes deeper search leads to worse results than shallower which is a phenomenon called search pathology. In this paper we present the results of our investigation of the causes for pathology in 8-puzzle and some of its variations.