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Lipoxygenases are a class of non-heme iron dioxygenases which catalyze the hydroperoxidation of fatty acids for the biosynthesis of leukotrienes and lipoxins. The structure of the 839-residue soybean lipoxygenase-1 was used as a template to model human 5-, 12-, and 15-lipoxygenases. A distance-based algorithm for placing side chains in a low homology environment (only the four iron ligands were...

Hugo: ALOX15 Other names: 15-LOX; EC 1.13.11.33; arachidonate omega 6-lipoxygenase; LOG15 Location: 17p13.3 Local order: Genes flanking ALOX15 in centromere to telomere direction on 17p13 are: MYBBP1A 17p13.3 MYB binding protein (P160) 1a, GGT6 17p13.2 homolog of gammaglutamyltransferase 6, LOC124974 17p13.2, thioredoxin 1 pseudogene 4, SMTNL2 17p13.2 smoothelin-like 2, ALOX15 17p13.2 arachidon...

Macrophage infiltration is a hallmark in the majority of solid tumors. Our studies demonstrated that macrophages that infiltrate human renal cells carcinoma (RCC) display markedly enhanced expression and activity of 15-lipoxygenase-2 (15-LOX2). Obtained data suggest that enhanced lipoxygenase activity in tumor-associated macrophages stimulates cancer inflammation and causes immune dysfunction.

Soybean lipoxygenases (soybean lipoxygenase-1) has been a well-studied enzyme because it is considered as model for mammalian lipoxygenases. In general, the soybean lipoxygenase-1 used in test of inhibitory activities various compounds. The present study provides bioinformatics approach comparison databases. Their physical and chemical parameters such molecular weight, theoretical pI, amino aci...