Micrographia is a common symptom in Parkinson’s disease, which manifests as either a consistent or progressive reduction in the size of handwriting or both. Neural correlates underlying micrographia remain unclear. We used functional magnetic resonance imaging to investigate micrographia-related neural activity and connectivity modulations. In addition, the effect of attention and dopaminergic ...

Nika N Danial1–3, Loren D Walensky2–5, Chen-Yu Zhang6, Cheol Soo Choi7,8, Jill K Fisher1–3, Anthony J A Molina9, Sandeep Robert Datta10,13, Kenneth L Pitter2–5, Gregory H Bird2–5, Jakob D Wikstrom9, Jude T Deeney11, Kirsten Robertson1–3, Joel Morash2–5, Ameya Kulkarni7,8, Susanne Neschen7,8, Sheene Kim7,8, Michael E Greenberg10, Barbara E Corkey11, Orian S Shirihai9, Gerald I Shulman7,8, Bradfo...

Meteor-scatter communication was first described in the pages of QST in 1953 as a means for communicating on dead 15 and 20 m bands. Hams soon realized that even more impressive results could be obtained at 6 and 2 m, where background noise levels are much lower and useful low-elevation gain is obtainable with relatively modest antennas. Early meteor-scatter (MS) contacts used CW and relied on ...

Complement 9 deficiency is the most common complement deficiency in Japan, but it is rare in western countries. Because of Korea’s geographical proximity to Japan, C9 deficiency in Korea has also been assumed to be common although this has never before been proven. We investigated complement deficiency in the serum samples of 6,159 Korean hospital outpatients. The deficiency was screened by a s...

Protein tyrosine phosphorylation is a key regulatory modification in metazoans, and the corresponding kinase enzymes have diversified dramatically. This diversification is correlated with a genome-wide reduction in protein tyrosine content, and it was recently suggested that this reduction was driven by selection to avoid promiscuous phosphorylation that might be deleterious. We tested three pr...

Background: MicroRNA (miR) dysregulation is found in Alzheimer's disease (AD). A disintegrin and metalloprotease 10 (ADAM10) prevents generation of amyloid β (Aβ) and decrease AD pathology. Results: miR-144 suppresses ADAM10 expression and is up-regulated by activator protein-1. Conclusion: miR-144 is negative regulator of ADAM10 and may be involved in AD pathogenesis. Significance: The first w...

1. Manifolds: 1/7/14 1 2. Tangent and Cotangent Spaces: 1/9/14 3 3. Vector Fields, One-Forms, and Riemannian Metrics: 1/14/14 6 4. The Lie Bracket and Riemannian Connections: 1/16/14 8 5. Existence and Uniqueness of the Riemannian Connection: 1/21/14 10 6. Tensor Fields, Parallel Transport, and Holonomy: 1/23/14 13 7. The Riemann Curvature Tensor: 1/28/14 15 8. Flatness: 1/30/14 17 9. Symmetrie...