1. Two hours after oral feeding of normotensive Wistar Kyoto rats with the converting-enzyme inhibitor SQ 14225 (1 and 10 mg/kg), an increase of angiotensin I plasma concentrations from 892 +/- 113 to 1660 +/- 167 and 2951 +/- 405 pg/ml was observed. 2. Administration of SQ 14225 with the drinking fluid overnight suppressed the pressor responses to intravenous angiotensin I, although the blood ...

Murine schistosomiasis is a granulomatous disease associated with high serum and granuloma angiotensin I-converting enzyme (ACE) activity. SQ 14225, a specific competitive inhibitor of ACE, was administered to normal mice and mice infected with Schistosoma mansoni to determine whether this compound could inhibit granuloma ACE activity and modify the size of the granulomatous response to schisto...

A genetic study of certain chlorophyll deficiencies in maize " (1925). Retrospective Theses and Dissertations. Paper 14225.

Dogs with thoracic caval constriction retain sodium and develop ascites and edema. The role of the renin-angiotensin-aldosterone system in this model of low output failure was evaluated before, during, and after administration of the new orally active converting enzyme inhibitor, 2-D-methyl-3-mercaptopropanoyl-L-proline (SQ 14225). The acute response to the initial oral dose of SQ 14225 (10 mg/...

1. The haemodynamic effects of oral converting enzyme inhibitor (SQ 14225) were assessed in eight patients with severe essential or renovascular hypertension. 2. Mean arterial pressure fell (149 +/- 5 to 127 +/- 8 mmHg, P less than 0.02), because of a fall in total peripheral resistance (6.9 +/- 0.53 to 5.7 +/- 0.40 kPa 1(-1)s m2) without a significant change in cardiac index. Two of the eight ...

bradykinin in man. Circulation 29: 66, 1964 32. Oparil S, Koerner T, O'Donoghue JK: Mechanism of angiotensin I converting enzyme inhibition by SQ 20,881 (Glu-Trp-ProArg-Pro-Gln, Ile-Pro-Pro) in vivo. Further evidence for extrapulmonary conversion. Hypertension 1: 13, 1979 33. Sancho JRE, Burton R, Barger AC, Haber E: The role of the renin-angiotensin-aldosterone system in cardiovascular homeost...

O O F High level information fusion for tracking and projection of multistage cyber attacks Shanchieh J. Yang *, Adam Stotz , Jared Holsopple , Moises Sudit , Michael Kuhl d a Department of Computer Engineering, Rochester Institute of Technology, 83 Lomb Memorial Dr., Rochester, NY 14623, USA b Information Fusion Division, Calspan-UB Research Center, 4455 Genesee Street, Buffalo, NY 14225, USA ...