Trimethoprim (TMP) has been widely used since the 1960s, both alone and in combination with sulfamethoxazole. Unfortunately, information regarding the role that cytochrome P450 enzymes (P450s) play in the formation of TMP primary metabolites is scarce. Hence, we undertook in vitro studies to identify and more fully characterize the P450s that catalyze formation of six TMP primary metabolites: T...

Human plasma butyrylcholinesterase (BChE) contributes to cocaine metabolism and has been considered for use in treating cocaine addiction and cocaine overdose. TV-1380 is a recombinant protein composed of the mature form of human serum albumin fused at its amino terminus to the carboxy-terminus of a truncated and mutated BChE. In preclinical studies, TV-1380 has been shown to rapidly eliminate ...

Continual improvement of oxygenators has been important in the growing demands of patient safety and support during cardiopulmonary bypass. The purpose of this study was to compare the Maxima 1380 oxygenator to the upgraded Maxima Plus oxygenator. Thirty-two adult patients were randomized to either the 1380 group or the Plus group. Information was recorded on the patients' weight, age, body sur...

During the past several years, our laboratory has studied the mechanism of immune suppression in the 4-hydroxy-3-nitrophenyl acetyl (NP) 1 system. In this model system, both cell-mediated and humoral immunity (1-3) have been analyzed. The findings have permitted integration of the data into a single linear scheme of cellular interactions (3-5). Based on the results obtained in our and other lab...

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The phytoplankton in warm oligotrophic regions of the open oceans is dominated by ,2-mm cells too small for efficient direct consumption by mesozooplankton. However, these primary producers are hypothetically linked to higher trophic levels via the cascading impacts of mesozooplankton grazing on intermediate consumers. To assess the magnitudes of these indirect trophic linkages, grazing experim...

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The implications of the f1(1285) − f1(1420) mixing for the K1(3P1) − K1(1P1) mixing angle is investigated. Based on the f1(1285)− f1(1420) mixing angle ∼ 50 suggested from the analysis for a substantial body of data concerning the f1(1420) and f1(1285), the masses of the K1( 3P1) and K1( 1P1) are determined to be ∼ 1307.35± 0.63 MeV and 1370.03± 9.69 MeV, respectively, which therefore suggests ...

Epoch Themes and Strategies for Studying the Biology of Stroke Recovery in the Poststroke Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2008 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Stroke doi: 10.1161/STROKEAHA.107.499962 2008;39:1380-1388; originally published online February 28, ...