Accurate determination of rates of de novo synthesis and degradation of cytochrome P450s (P450s) has been challenging. There is a high degree of variability in the multiple published values of turnover for specific P450s that is likely exacerbated by differences in methodologies. For CYP3A4, reported half-life values range from 10 to 140 hours. An accurate value for kdeg has been identified as ...

Department of Genetic Medicine, Women’s and Children’s Hospital, North Adelaide, South Australia, Australia, Department of Paediatrics and Department of Molecular Biosciences, University of Adelaide, South Australia, Australia, Departments of Neurology, Molecular Physiology and Biophysics and Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, USA, Epilepsy Research Instit...

A novel anaerobic, thermophilic, Fe(III)-reducing, CO-utilizing bacterium, strain 1315(T), was isolated from a hot spring of Geyser Valley on the Kamchatka Peninsula. Cells of the new isolate were Gram-positive, short rods. Growth was observed at 52-70 degrees C, with an optimum at 65 degrees C, and at pH 5.5-8.5, with an optimum at pH 6.5-7.2. In the presence of Fe(III) or 9,10-anthraquinone 2...

4.3. Manganese Oxide-Based Compounds 1291 4.3.1. MnO2-Type Compounds 1291 4.3.2. Ternary Lithiated LixMnOy Compounds 1293 4.4. Vanadium Pentoxide V2O5 1298 4.4.1. V2O5 Structure 1298 4.4.2. LixV2O5 Bulk Phases 1300 4.4.3. LixV2O5 Crystallized Thin Films 1303 4.5. Titanium Oxide-Based Compounds 1305 4.5.1. Lithium Titanate Li4Ti5O12 1306 4.5.2. TiO2 Anatase 1308 5. Phospho-olivine LiFePO4 Compou...

This paper presents an account of a self-access language teaching scheme operated at the University of Bologna during the last three years. The main goal of the D.I.A.P.A.S.O.N. (Distributed, Interactive, And Personalised Audio-visual Study Over Network) project is to teach English to university students up to intermediate level, by building a self-access environment freely available to learner...

Background and purpose: A likely explanation for the increase in lens fluorescence with aging and the acceleration of this process in patients with diabetes, is that lens proteins are altered by non-enzymatic glycosylation and the further steps of the Maillard reaction. Thus, the lens fluorescence intensity appears to represent a cumulative index of glycemia over the entire lifetime of the subj...

Multiple representations and multi-media can support learning in many di€erent ways. In this paper, it is claimed that by identifying the functions that they can serve, many of the con ̄icting ®ndings arising out of the existing evaluations of multi-representational learning environments can be explained. This will lead to more systematic design principles. To this end, this paper describes a fu...

[This corrects the article on p. 1315 in vol. 11, PMID: 28769551.].