The developing forebrain roof plate (RP) contains a transient signaling center, perturbations in which have been linked to holoprosencephaly (HPE). Here, we describe a novel domain of retinoic acid (RA) signaling that is specific to the chick RP and demonstrate that RA signaling is sufficient for inducing characteristics of the RP in ectopic locations. We further demonstrate that, unlike what h...

Cancer initiationandmaintenanceof the transformedcell state depend on altered cellular signaling and aberrant activities of transcription factors (TFs) that drive pathological gene expression in response to cooperating genetic lesions. Deciphering the roles of interacting TFs is therefore central to understanding carcinogenesis and for designing cancer therapies. Here, we use an unbiased genomi...

AIMS MK-1293 is an insulin glargine that has an amino acid sequence identical to that of Lantus, the originator insulin glargine. Two euglycaemic clamp studies, 1 in subjects with type 1 diabetes (T1D) and 1 in healthy subjects, were conducted to demonstrate pharmacokinetic (PK) and pharmacodynamic (PD) similarity between MK-1293 and Lantus commercially procured in both the European Union (EU-L...

Objective: To review empirical findings on oppositional defiant disorder (ODD) and conduct disorder (CD). Method: Selected summaries of the literature over the past decade are presented. Results: Research on ODD and CD during the past decade has addressed the complexity involved in identifying the primary risk factors and developmental pathways to disruptive behavior disorders (DBD). In some do...

The efficacy of BAY 57-1293, a novel non-nucleosidic inhibitor of herpes simplex virus 1 and 2 (HSV-1 and HSV-2), bovine herpesvirus and pseudorabies virus, was studied in the guinea pig model of genital herpes in comparison with the licensed drug valaciclovir (Valtrex). Early therapy with BAY 57-1293 almost completely suppressed the symptoms of acute HSV-2 infection, and reduced virus shedding...

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INTRODUCTION ............................................................................................. 1289 I. THE NATURE AND COMPONENTS OF FIDUCIARY RELATIONSHIPS AND THE RISKS THE RELATIONSHIPS POSE TO BOTH PARTIES .......... 1293 A. Components of Fiduciary Relationships .................................... 1293 B. While Fiduciaries’ Services Provide Benefits to Entrustors, the Services I...

, 1293 (1997); 275 Science et al. Antoine Bechara, Advantageous Strategy Deciding Advantageously Before Knowing the www.sciencemag.org (this information is current as of October 27, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/275/5304/1293 version of this article at: including high-resolution figures, can be found in...

, 1293 (1997); 275 Science et al. Antoine Bechara, Advantageous Strategy Deciding Advantageously Before Knowing the www.sciencemag.org (this information is current as of March 31, 2008 ): The following resources related to this article are available online at http://www.sciencemag.org/cgi/content/full/275/5304/1293 version of this article at: including high-resolution figures, can be found in t...