Resistance to radiation is a major problem in cancer treatment. The mechanisms of radioresistance remain poorly understood; however, mounting evidence supports a role for microRNAs (miRNAs) in the modulation of key cellular pathways mediating the response to radiation. The present study aimed to identify specific miRNAs and their effect on radioresistant cells. The global miRNA profile of an es...

Ototoxicity is known to cause permanent loss of vestibule function through degeneration of sensory hair cells (HCs). However, functional recovery has been reported during washout after chronic ototoxicity, although the mechanisms underlying this reversible dysfunction are unknown. Here, we study this question in rats chronically exposed to the ototoxic compound 3,3′-iminodipropionitrile (IDPN)....

fleas are the most common and important external parasites worldwide and also serves as vectors of various pathogens for humans and animals. the study aimed to determine the prevalence of pulex irritants in sheep herds and residential areas of villages in kurdsitan province, iran. a total of 2,900 sheep were randomly selected from 48 flocks and 630 residential areas of 18 villages from november...

, 1323 (2009); 324 Science et al. Jakob Fuhrmann the Heat-Shock Regulator CtsR McsB Is a Protein Arginine Kinase That Phosphorylates and Inhibits This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained ...

Herb-drug interaction related with the drugs used to treat HIV patients was speculated in the present study. Therefore, zidovudine (AZT) was selected as an example, and in vitro incubation model was utilized to evaluate the inhibitory effect of herbal component methylophiopogonanone A towards the metabolism of AZT. The results showed the concentration-dependent inhibition of methylophiopogonano...

Proteinaceous material usually accounts for much of the total nitrogen and organic carbon in marine sediments. Thus, decomposition of protein is frequently investigated as a measure of labile organic matter turnover. The fraction of protein that escapes remineralization to CO2 undergoes transformations that may reflect pathways of preservation in sedimentary environments. We analyzed the molecu...

Two high galactic latitude B-type stars, PG 1323−086 and PG 1704+222, are analysed from low and medium resolution optical spectra and Strömgren photometry. A differential abundance analysis for He, C, N, O, Mg, Al, and Si reveals that the He abundance is close to solar while metal underabundances relative to the solar value of typically 1.3 and 1.2 dex for PG 1323−086 and PG 1704+222, respectiv...