نتایج جستجو برای: 12 Adipolin
تعداد نتایج: 580775 فیلتر نتایج به سال:
Obese states characterized by chronic inflammation are closely linked to the development of metabolic dysfunction. We identified adipolin/CTRP12 as an insulin-sensitizing and anti-inflammatory adipokine. Although obese conditions down-regulate adipolin expression, its molecular mechanism is largely unknown. Here we show that the transcriptional regulator Krüppel-like factor (KLF) 15 is involved...
Obesity is a major risk factor for the development of insulin resistance and type 2 diabetes. Adipose tissue secretes various bioactive molecules, referred to as adipokines, whose dysregulation can mediate changes in glucose homeostasis and inflammatory responses. Here, we identify C1qdc2/CTRP12 as an insulin-sensitizing adipokine that is abundantly expressed by fat tissues and designate this a...
Regular exercise is a good strategy for treating many metabolic disorders, including type 2 diabetes and obesity. Some part of the beneficial effects of exercises are due to endocrine exercise, including fatty tissue which plays an important role in regulating energy metabolism, body composition, and insulin resistance [1]. The adipose tissue, as an active endocrine and paracrine tissue as well...
In recent years, the rates of obesity and related illnesses have increased in the country, with 71% of Iranian women and men suffering from overweight and obesity [1]. The epidemic of obesity and the prevalence of disorders and associated illnesses have led to an increase of 30% in health care and obesity costs in obese people compared to normal weight counterparts [2]. Therefore, harm to indiv...
Krüppel-like factor 3 (KLF3) is a transcriptional regulator that we have shown to be involved in the regulation of adipogenesis in vitro. Here, we report that KLF3-null mice are lean and protected from diet-induced obesity and glucose intolerance. On a chow diet, plasma levels of leptin are decreased, and adiponectin is increased. Despite significant reductions in body weight and adiposity, wil...
Background: The C1q complement/TNF-related protein (CTRP) superfamily is a newly diagnosed adipokine with anti-inflammatory, insulin sensitivity, and glucose lowering effects. This study aimed to assess the plasma circulating levels of CTRP12 in type 2 diabetic (T2D) patients and healthy subjects. Methods: In this case-control study, plasma concentration of CT...
Background: Adipulin is a hormone secretd by fat cells that acts as a metabolic regulator with anti-inflammatory properties and is reduced through obesity, diabetes and inflammation. Therefore, the aim of this study was to compare the effect of high and moderate intensity aerobic exercise on serum adipolin levels and some indicators of metabolic syndrome in obese women. Methods: In this quasi-...
Secretion of pro-inflammatory and anti-inflammatory cytokines play a critical role in the regulation of metabolic conditions. This study examines the effect of eight weeks aerobic training on Adipolin cytokine and insulin resistance index in type 2 diabetic male rats. Eighteen 8-10 weeks Wister rats with 200-220 gr are selected and they divided equaly into two diabetes [DBT] and control [CON] g...
Adipolin, neprilysin, and chemerin have pleiotropic properties; therefore, their concentrations may influence health complications associated with obesity. The study aimed to search the relationship between adipokine levels anthropometric metabolic parameters as well blood pressure values, taking into account of gender age. group consisted 88 people aged 30–60 years. It was found that concentra...
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