CC-122 hydrochloride is a novel pleiotropic pathway modifier compound that binds cereblon, a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex. CC-122 has multiple activities including modulation of immune cells, antiproliferative activity of multiple myeloma and lymphoma cells, and antiangiogenic activity. CC-122 is being developed as an oncology treatment for hematologic mal...

Future of Avian Genetic Resources Collections: Archives of Evolutionary and Environmental History.—In the past 30 years, genetic resources collections (GRCs) have shiĞ ed position within ornithology, from a novel supplement to traditional voucher collections to a major core source of raw material fueling multiple subdisciplines. The demand for specimens from GRCs now greatly exceeds both the de...

The present study aims to explore the possible mechanisms underlying the multidrug resistance characteristic of Cryptosporidium parvum by detecting the presence of ATP-binding cassette (ABC) protein encoding genes, especially one that shows high similarity to members belonging to the multidrug resistance protein (MDR) and multidrug resistance associated protein (MRP) subfamilies. PCR using ABC-...

Multiple sclerosis (MS) is an inflammatory and autoimmune disease.MS is characterized by blood brain barrier breakdown, inflammation, axonal injury, degeneration of the myelin sheath and etc. A significant association between inflammation and degeneration of neurons is observed in the brain. Also active MS lesions always associated with inflammation thus inflammation is a target for treatment o...

Methods The data sources and methods of estimation used in this study are the same as those used for the 1988 calculations. Birth data were taken from publications of the NCHS,5 which obtains birth certificate information from state vital statistics agencies. The most recent NCHS data tabulate race according to the race of the mother rather than the child, and the NCHS has retabulated data from...

Background and objectives: Low social status increases risk of disease due, in part, to the psychosocial stress that accompanies feeling subordinate or poor. Previous studies report that chronic stress and chronically elevated cortisol can impair cardiovascular and immune function. We test whether lower status is more benign in small-scale, relatively egalitarian societies, where leaders lack c...

a Scientifi c Resource.—Bird collections were founded and built during the heyday of global exploration. The mission of these collections through most of their history has been to document avian diversity and its distribution and to serve as a resource for research and education. As bird collections became established and grew, ornithology itself became a scientifi c discipline and broadly expa...

microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular c...