Upon muscle injury, the high mobility group box 1 (HMGB1) protein is upregulated and secreted to initiate reparative responses. Here we show that HMGB1 controls myogenesis both in vitro and in vivo during development and after adult muscle injury. HMGB1 expression in muscle cells is regulated at the translational level: the miRNA miR-1192 inhibits HMGB1 translation and the RNA-binding protein H...

Histone deacetylases (HDACs) regulate a broad range of biological processes through removal of acetyl groups from histones as well as non-histone proteins. Our previous studies showed that Hdac1 and Hdac2 are bound to promoters of key renal developmental regulators and that HDAC activity is required for embryonic kidney gene expression. However, the existence of many HDAC isoforms in embryonic ...

We have engineered polymers called ReGeneraTing Agents (RGTAs), which mimic the protecting and potentiating properties of heparan sulfates toward heparin-binding growth factors (HBGF). RGTAs have been shown to optimize cell growth and regulate collagen production in vitro. Here, we studied relationships between RGTA structure and collagen-type expression in aortic smooth muscle cells by using t...

Abstract With BS 1192:2007 and even more so with PAS 1199-2:2013 1192-3:2014, the concept of Common Data Environment (CDE) order (project, construction or management that is). Originating from a standard dedicated to design (BS 1192:2007) although its has been extended information in general: Capex (strategy, project, construction: 1192-2) Opex (exercise: 1192-3), CDE, as it is understood today...

declarator, 181, 1190access-specifier, 231, 1192additive-expression, 118, 1183alias-declaration, 139, 1186alignment-specifier, 175, 1189and-expression, 122, 1183asm-definition, 171, 1188assignment-expression, 125, 1184assignment-operator, 125, 1184attribute, 175, 1189attribute-argument-clause, 175, 1189attribute-declaration, 139, 1186attribute-lis...

This study investigated the hydrocarbonoclastic microbial community present on weathered crude oil and their ability to degrade weathered oil in seawater obtained from the Gulf St. Vincent (SA, Australia). Examination of the native seawater communities capable of utilizing hydrocarbon as the sole carbon source identified a maximum recovery of just 6.6 × 10 1 CFU/ml, with these values dramatical...

1Department of Joint Research Laboratory of Clinical Medicine and 2Department of Quality and Safety in Healthcare, Fujita Health University Hospital, Toyoake 470-1192; 3Department of Pediatrics, Fujita Health University School of Medicine, Toyoake 470-1192; 4Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo 208-0011; and 5Department of Microbiology and Medical Zool...

I. The Problem with Best Interests: A Framework; a Justificatory Idiom; and a Problem ................................. 1192 A. Framework: The Three Dimensions of State Interventions Aimed at Influencing Reproduction .............................................................. 1192 B. Justificatory Idiom: Best Interests of the Resulting Child Justifications, Their Attraction and Prominence .....