The suppression of hepatic cytochrome P450 (P450) expression during inflammatory and infectious diseases and the relief of this suppression by successful disease treatment have been previously demonstrated to impact drug disposition. To address this clinically relevant phenomenon preclinically, the effect of proinflammatory cytokines on P450 isoenzymes in human hepatocytes has been examined by ...

Aim. A new manufacturing method aiming at to producing more flexible and resistant NiTi endodontic instruments has been recently developed (Hyflex, produced with CM wire). The purpose of the study was to determine whether this new manufacturing method produces NiTi instruments (Hyflex) of superior flexibility and/or superior resistance to cyclic fatigue, when compared with instruments produced ...

Contemporary cognitive science attempts to provide computational models that describe how consciousness and emotion constitute adaptive behavior. Given the recent neurobiological view that highlights the fact that the cognitive and emotional regions of the brain work together to achieve conscious behavior, it was shown that signal-detection theory (SDT) can effectively capture the notion of the...

Diet can significantly influence athletic performance, but recent research developments have substantially changed our understanding of sport and exercise nutrition. Athletes adopt various nutritional strategies in training and competition in the pursuit of success. The aim of training is to promote changes in the structure and function of muscle and other tissues by selective modulation of pro...

Mild COPD is an asymptomatic disease but as oxidant antioxidant imbalance increases the severity of the disease also increases. The aim of the present study was to evaluate the oxidant antioxidant imbalance in mild and moderate COPD groups. The present study included 73 patients with COPD out of which 32 were of Mild impairment and 41 were suffering from Moderate COPD. The results indicated tha...

Ethanol extracts of two indigenous Nigerian plants Hibiscus sabdariffa and Azadirachta indica extracted using the soxhlet extraction method, were used to stain malaria parasites. The extracts were made with different percentages of ethanol (96%, 75%, 50% and 30%) and diluted to various concentrations. There was no previous record known on the use of H. saddariffa & A indica in staining intestin...

The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical ‘extrinsic’ apoptosis pathway, we demonstrated that in the absence of intracellular apoptotic signaling it is capable of activating a common nonapoptotic death pathway, w...

Great smiles have harmony, symmetry, and a broadness consistent with the individual’s facial form, morphology, and balance. Smiles communicate, are expressive, and especially beautiful when full. People do not perceive narrow arch smiles to be appealing. A proportional smile fills the lip embrasures and eliminates black triangles. We see this as beauty in nature, and such symmetry is preferred ...

A 37-year-old man with symptoms of cardiovascular disease applied to our hospital. Seven years ago, he had undergone combined kidney and pancreas transplantation. Afterwards, 4 years ago, his renal transplantation was repeated because of rejection. Coronary artery angiography revealed two-vessel coronary artery stenosis. We performed coronary artery bypass grafting to treat the coronary artery ...