We previously found that 3,9-bis(N,N-dimethylcarbamoyloxy)-5H- benzofuro[3,2-c]quinoline-6-one (KCA-098) inhibited bone resorption in organ culture. In this study, to determine if KCA-098 is therapeutically applicable for the treatment of osteoporosis, we compared the effect of KCA-098 on bone tissues with that of ipriflavone, a drug that is clinically used for the treatment of osteoporosis. Bo...

Interactions of KCA-098 with heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CyD) in solution and in the solid state were studied by the solubility method, UV and fluorescence spectroscopy, powder X-ray diffractometry, and thermal analysis. The KCA-098/DM-beta-CyD system showed an A(L) type solubility diagram with stability constants of 5870 and 2220 M(-1) in aqueous and 10% methanol solut...

The thickness of the entrainment zone at the top of the atmospheric mixed layer is analyzed using measurements made with a ground-based lidar during the BLX-83 and CIRCE field programs. When the entrainment-zone depth normalized by mixed-layer depth is plotted as a function of the entrainment rate normalized by the convective velocity scale, with time as a parameter, a hysteresis curve results....

The evolution of reciprocal altruism probably involved the evolution of mechanisms to detect cheating and remember cheaters. In a well-known study, Mealey, Daood, and Krage (1996) observed that participants had enhanced memory for faces that had previously been associated with descriptions of acts of cheating. There were, however, problems with the descriptions that were used in that study. We ...

A new benzofuroquinoline derivative, 3,9-bis(N,N-dimethylcarbamoyloxy)-5H-benzofuro[3,2-c]quinoli ne-6-one (KCA-098), shows poor oral absorption due to practical insolubility in water. In this study, a co-grinding technique employing a water-soluble polymer was used for improvement of the dissolution rate of KCA-098. Powder X-ray diffraction patterns and IR spectra of KCA-098 showed the convers...

Gamma-ray pulsar halos are ideal indicators of cosmic-ray propagation in localized regions the Galaxy and electron injection from wind nebulae. HESS~J1831$-$098 is a candidate halo observed by both H.E.S.S. HAWC experiments. We adopt flux map Galactic plane survey spectrum measurements \textit{Fermi}-LAT to study HESS~J1831$-$098. find that meets all criteria for halo. The diffusion coefficient...

Müge Taşdemir Mete E, Kısa U, Baştopçu M. The relationship of inferior mesenteric artery occlusion with abdominal aortic aneurysm diameter and intramural thrombus thickness. Turk J Vasc Surg 2022; 31(2): 098-102. http://dx.doi.org/10.9739/tjvs.2022.1196

XMM-Newton and Chandra observations of the transient 7.8 s pulsar XTE J1829−098 are used to characterize its pulse shape and spectrum, and to facilitate a search for an optical or infrared counterpart. In outburst, the absorbed, hard X-ray spectrum with Γ = 0.76 ± 0.13 and NH = (6.0 ± 0.6) × 10 22 cm is typical of X-ray binary pulsars. The precise Chandra localization in a faint state leads to ...