a quantitative structure-activity relationship (qsar) study was conducted for the prediction of inhibitory activity of 1-phenyl[2h]-tetrahydro-triazine-3-one analogues as inhibitors of 5-lipoxygenase. the inhibitory activities of the 1-phenyl[2h]-tetrahydro-triazine-3-one analogues modeled as a function of molecular structures using chemometrics methods such as multiple linear regression (mlr) ...

A quantitative structure-activity relationship (QSAR) study was conducted for the prediction of inhibitory activity of 1-phenyl[2H]-tetrahydro-triazine-3-one analogues as inhibitors of 5-Lipoxygenase. The inhibitory activities of the 1-phenyl[2H]-tetrahydro-triazine-3-one analogues modeled as a function of molecular structures using chemometrics methods such as multiple linear regression (MLR) ...

The NCNN group is an essential part of various heterocycles bearing high biological activities. 1,2,4-Triazines and their condensed derivatives found applications as pharmaceuticals and in agriculture. For example vardenafil ñ phosphodiesterase inhibitor, is useful in the treatment of male erectile dysfunctions (1), apazone exhibit anti-inflammatory and analgesic actions (2), lamotrigine is use...

OBJECTIVES The present study was aimed to evaluate the anti-hyperlipidemic activity of newly synthesized tricyclic benzothieno 1, 2, 3-triazine derivatives namely CP-1 (3-(methyl)- 5,6,7,8-tetrahydro,3H-benzo[4,5] thieno [2,3-d][1,2,3] triazin-4-one), CP-2 (3-(ethyl)- 5,6,7,8-tetrahydro,3H-benzo[4,5] thieno [2,3-d][1,2,3] triazin-4-one) and CP-6 (3-(2-chloro phenyl)-5,6,7,8-tetrahydro,3H-benzo[...

The aim of this work is to develop methods synthesis 3-arylaminomethyl-1-(2-oxo-2-arylethyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-1-ium bromides and aryl-(4-R1-phenyl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd]azulen-1-ylmethyl)-amines study their antimicrobial activity against strains gram-positive gram-negative bacteria as well yeast fungi.
 Materials methods. 1Н NMR sp...

Amongsuch compounds was included benarthin4'5), an inhibitor of pyroglutamyl peptidase (PGpeptidase). Wehave further continued screening for inhibitors of PG-peptidase, and discovered another new inhibitor, which we named pyrizinostatin, from culture filtrate of the microbial strain SA2289, which had been isolated from a marine soil and confirmed to belong to the genus Streptomyces. The structu...

The title compound, 4-amino-5-benzoyl-1-benzyl-2-(4,5,6,7-tetrahydro-1H-indol-2-yl)- 1H-pyrrole-3-carbonitrile, was synthesized for the first time in a 40% yield by reaction of N-benzyl-3-imino-5,6,7,8-tetrahydro-3H-pyrrolo[1,2-a]indol-1-amine and 1-chloroacetophenone K2CO3/MeCN system (reflux, 6 h). product characterized 1H-NMR, 13C-NMR, IR spectroscopy, elemental analysis.