Aims: The purpose of this study was to determine the effect of exercise training with resveratrol on PGC-1α and PDK4 gene expression in gastrocnemius muscle tissue of elderly type 2 diabetic rats. Materials and Methods: 42 male rats with type 2 diabetes, 250 to 300 g were divided into 6 groups; healthy-control, diabetic-control, diabetic+interval exercise, Diabetic+Supplement, Diabetic+interva...

Background: Breast cancer, which is a major cancer for women, affects the angiogenesis process. Exercise training can decrease the process of angiogenesis in tumor tissue. The aim of present study was to investigate the effects of 8 weeks of aerobic training on HIF-1α, miR-21 and VEGF gene expression in female Balb/c mice with breast cancer. Materials and Methods: 16 female Balb/c mice (age: 3...

Background: Due to the uncertainty of the impact of thyme supplementation on endurance sport performance, despite its high antioxidant property, this study was conducted on rats to provide a tonic supplement of thyme extract and also to investigate its effect on the PGC-1α gene expression. Methods: In this experimental study 40 adult male Wistar rats as statistical samples were randomly classi...

Objective: Decreased physical activity coupled with increased High‐Fat Diet (HFD) intake prompts obesity. Current research suggests that changing White Adipose Tissue (WAT) to brown promotes energy expenditure to counter obesity. The purpose of this study was to investigate the effects of aerobic Progressive training and Capsaicin (Cap) on Peroxisome proliferator-activated receptor gamma coacti...

Introduction: Exercise training with different intensity regulates metabolism at the cellular level by regulating the expression of genes involved in mitochondrial biogenesis in diabetic patients. The aim of this study was to evaluate the effect of 4 weeks of high intensity interval training on the expression of PGC-1α, CS and p-53 genes in the cardiomyocytes of obese male rats with type 2 diab...

 Background and Aim: One of the most common metabolic diseases is diabetes with hyperglycemic properties and endogenous insulin dysfunction. This study aimed to evaluate the effect of 10 weeks HIIT on HIF-1α gene expression in heart tissue of rats with type 2 diabetes. Methods: In this experimental study, 36 Wister rats with a mean weight of 200±58g were randomly assigned to control, diabetic,...

Background and Objectives: Myocyte enhancer factor 2c activates the genes of the slow-twitch muscle, the muscle which plays role in endurance activity. Therefore, the aim of this study was to evaluate the effect of a program of intensive endurance activity on MEF2c gene expression in fast and slow twitch skeletal muscles in wistar rats. Materials and Methods: In this experimental study, 14 mal...

Background: Cardiomyopathy is one of adverse effects of diabetes that associated with cardiac muscle metabolism and function disruption. Exercise training decreases adverse effects of diabetes on heart by changing genes involved in cardiac metabolism and increasing myokines secretion. So, the aim of this study was to investigate of 8 weeks aerobic training on cardiac PGC-1α gene expression and ...