Introduction: PGC-1α gene plays an important role in regulating cellular energy metabolism and stimulating the increased cell mitochondrial mass. Understanding the status of this gene polymorphism in non-athletic male adolescents may be helpful in choosing and identifying the sport talented male adolescents. The purpose of the present study was to investigate possible association between PGC-1α...

Aims: The purpose of this study was to determine the effect of exercise training with resveratrol on PGC-1α and PDK4 gene expression in gastrocnemius muscle tissue of elderly type 2 diabetic rats. Materials and Methods: 42 male rats with type 2 diabetes, 250 to 300 g were divided into 6 groups; healthy-control, diabetic-control, diabetic+interval exercise, Diabetic+Supplement, Diabetic+interva...

Abstract Background: PGC-1α is involved in the regulation of several metabolic processes and its reduced expression has been observed in early stages of type 2 diabetes, (T2D). Changes in activity of PGC-1α, probably due to its polymorphisms, have extensive effects on metabolic processes in people with T2D. The association of rs2970847 polymorphism of PGC-1α gene with T2D has been investigat...

Background: Due to the uncertainty of the impact of thyme supplementation on endurance sport performance, despite its high antioxidant property, this study was conducted on rats to provide a tonic supplement of thyme extract and also to investigate its effect on the PGC-1α gene expression. Methods: In this experimental study 40 adult male Wistar rats as statistical samples were randomly classi...

Background: Breast cancer, which is a major cancer for women, affects the angiogenesis process. Exercise training can decrease the process of angiogenesis in tumor tissue. The aim of present study was to investigate the effects of 8 weeks of aerobic training on HIF-1α, miR-21 and VEGF gene expression in female Balb/c mice with breast cancer. Materials and Methods: 16 female Balb/c mice (age: 3...

 Background and Aim: One of the most common metabolic diseases is diabetes with hyperglycemic properties and endogenous insulin dysfunction. This study aimed to evaluate the effect of 10 weeks HIIT on HIF-1α gene expression in heart tissue of rats with type 2 diabetes. Methods: In this experimental study, 36 Wister rats with a mean weight of 200±58g were randomly assigned to control, diabetic,...

Objective: Decreased physical activity coupled with increased High‐Fat Diet (HFD) intake prompts obesity. Current research suggests that changing White Adipose Tissue (WAT) to brown promotes energy expenditure to counter obesity. The purpose of this study was to investigate the effects of aerobic Progressive training and Capsaicin (Cap) on Peroxisome proliferator-activated receptor gamma coacti...