benzodiazepine overdose is the most commonly encountered drug overdose in iran. it has been reported by many authors that flumazenil possesses highly specific antagonistic activity on central benzodiazepine receptors. we conducted a prospective study on 150 patients brought to the toxicology emergency ward in loghman-hakim hospital with benzodiazepine overdose to assess the efficacy of flumazen...

Benzodiazepine overdose is the most commonly encountered drug overdose in Iran. It has been reported by many authors that flumazenil possesses highly specific antagonistic activity on central benzodiazepine receptors. We conducted a prospective study on 150 patients brought to the toxicology emergency ward in Loghman-Hakim hospital with benzodiazepine overdose to assess the efficacy of flu...

A conjugate of the high affinity benzodiazepine receptor ligand Ro 15-1788 and the fluorescent 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) moiety was synthesized. This novel compound (BD 623) exhibited excitation and emission maxima at 486 and 542 nm, respectively, and possessed fluorescent properties that are dependent upon the polarity of its environment. BD 623 bound reversibly to benzodiazepine...

SUZUKI, H. Effects of a Benzodiazepine Antagonist, Ro 15-1788, on Hippocampal Field Potentials in Freely Moving Rats. Tohoku J. Exp. Med., 1991, 165 (4), 261-270 Effects of a benzodiazepine receptor agonist (diazepam) and an antagonist (Ro 15-1788, flumazenil) administered separately or in combination on field potentials recorded from the hippocampal dentate area were examined in unanesthetized...

Central type benzodiazepine receptors were studied in 9 patients with Friedreich's ataxia and 12 healthy subjects using positron emission tomography (PET) and [11C]Ro 15-1788, a specific antagonist of the central type benzodiazepine receptors, as radioligand. A standard PET procedure was used in 5 patients and 8 controls to obtain brain kinetics of the total binding of the radioligand. The rema...

Rhesus monkeys were trained to discriminate injections of saline from those of 8-carboline-3-carboxylic acid ethyl ester (8-CCE), a compound that binds to the benzodiazepine receptor, but often has actions opposite to those of the benzodiazeplnes. A benzodlazepine agonist midazolam and low doses of a specific benzodiazepine antagonist, Ro 15-1788, reversed the discriminative effects of 8-CCE. H...