a series of cyclic analogues of bioactive thiosemicarbazide derivatives have been synthesized as potential antimycobacterial agents. the 4-amino-1,2,4-triazole-5-thione analogues (ia-f) were prepared by heating a mixture of thiocarbohydrzide and appropriate carboxylic acids. reaction of thiocarbohydrazide with γ-ketoesters in the presence of sodium methoxide furnished triazolopyridazine derivat...

the series of 3-(substitutedphenyl)-n-(4h-1,2,4-triazol-4-yl)acrylamide compounds were prepared byreaction of 4-amino-1,2,4-triazole with acetyl chloride followed by claisen-schmidt condensation reactionwith different aromatic aldehydes. the structures of new compounds were confirmed by ir, 1h-nmr and13c-nmr spectral data. anti-bacterial and anti-fungal activities were evaluated and compared wi...

two novel 3-amino-5-(4-choloro-2-phenoxyphenyl)-4h-1,2,4-triazole derivatives were prepared and their anticonvulsant activity was measured by evaluation of the ability of these compounds to protect mice against convulsion induced by lethal doses of pentylenetetrazole (ptz). diazepam (sigma) was considered as a positive control drug with anticonvulsant effect [ed50 = 1.2 (0.5-1.9) mg/kg]. amongs...

starting from readily available 2-substituted-4-methylthiazole-5-carboxylic acid hydrazide (1), the title compounds were prepared. the reaction of compound 1 (r=ch3) with formic acid yielded 1-(formyl)-2-(2,4-dimethylthiazole-5-carboxyl) hydrazine (2). refluxing the latter with phosphorous pentasulfide in xylene afforded compound 3, the reaction of compound 2 with phosphorous pentoxide afforded...

Purpose: To synthesize new triazole derivatives in order to overcome the problem of side effects antimicrobial agents and microbial resistance, while broadening spectrum activity.
 Methods: The starting triazole, compound 1, was prepared through click chemistry reacted with chloroacetyl chloride yield II. Triazole 1 acids aldehydes produce oxadiazole (III) azomethine (IV) which cyclized ac...

The new ligands, 1-(4-isopropyl phenyl)-4-(2-pyridyl)-1,2,3-triazole, 1 and 1-(mesityl)-4-(2-pyridyl)-1,2,3-triazole, 2 were prepared by the reactions of the respective azides with 2-ethynylpyridine following the "click method". These ligands together with the reported ligands 1-(phenyl)-4-(2-pyridyl)-1,2,3-triazole, 3 and 1-(benzyl)-4-(2-pyridyl)-1,2,3-triazole, 4 were reacted with palladium a...

Oligonucleotides containing internal triazole-3'-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5'-side of the triazole does not stabilise duplexes. Triazole-LNA confers great resistance towards enzymatic degradation relative to LNA alone.

a series of 2-(4-nitro-1-imidazolylmethyl)-1,3,4-oxadiazole, 1,3,4-triazole and 3-(4-nitro-1-imidazolylmethyl)-1,2,4-triazole derivatives were synthesized and tested for their antimicrobial activity. some of the tested compounds were active against staphylococcus aureus, staphylococcus epidermidis, bacillus subtilis, clostridium difficile, aspergillus niger and cryptococcus neoformans.

The triazole core is one of the most imperative and well known heterocycles which composed nitrogen atom forms natural products with medicinal claims. Triazole moiety present as a principal structural component in drug categories such antimicrobial, anti-inflammatory, analgesic, antineoplastic, antimalarial, antiviral, antihypertensive, local anaesthetic, antianxiety, anti-Parkinson′s, antidepr...