نتایج جستجو برای: 1(h3)

تعداد نتایج: 28  

Journal: :Cell reports 2014
Hyungjun Jeon Vladimir Vigdorovich Sarah C Garrett-Thomson Murali Janakiram Udupi A Ramagopal Yael M Abadi Jun Sik Lee Lisa Scandiuzzi Kim C Ohaegbulam Jordan M Chinai Ruihua Zhao Yu Yao Ying Mao Joseph A Sparano Steven C Almo Xingxing Zang

B7x (B7-H4 or B7S1) is a member of the B7 family that can inhibit T cell function. B7x protein is absent in most normal human tissues and immune cells, but it is overexpressed in human cancers and often correlates with negative clinical outcome. The expression pattern and function of B7x suggest that it may be a potent immunosuppressive pathway in human cancers. Here, we determined the crystal ...

2014
Jonathan Audet Gary Wong Han Wang Guangwen Lu George F. Gao Gary Kobinger Xiangguo Qiu

Ebola virus (EBOV) causes severe viral hemorrhagic fever in humans and non-human primates, with a case fatality rate of up to 88% in human outbreaks. Over the past 3 years, monoclonal antibody (mAb) cocktails have demonstrated high efficacy as treatments against EBOV infection. One such cocktail is ZMAb, which consists of three mouse antibodies, 1H3, 2G4, and 4G7. Here, we present the epitope b...

2015
Vikash Singh Pradipta Bhakta Sabir Saeed Rajesh Kumar Jain

Vikash Singh1, Pradipta Bhakta1*, Sabir Saeed2, Rajesh Kumar Jain3 1Department of Anaesthesia and Intensive care, Our Lady of Lourdes Hospital, Drogheda, Ireland 2Department of Anesthesiology and Perioperative Medicine and Pain Management, University of Saskatchewan, Moose Jaw Union Hospital, 455 Fairford Street E S6H 1H3, Canada 3Locum Consultant, Adelaide and Meath Hospital, Department of Ana...

Journal: :The Japanese Journal of Ergonomics 2016

2013
Chun-hong Yin Li-ting Qin Mei-yu Sun Yu-long Gao Xiao-le Qi Hong-lei Gao Yong-qiang Wang Xiao-mei Wang

BACKGROUND Avian reovirus (ARV) causes arthritis, tenosynovitis, runting-stunting syndrome (RSS), malabsorption syndrome (MAS) and immunosuppression in chickens. σB is one of the major structural proteins of ARV, which is able to induce group-specific antibodies against the virus. METHODS AND RESULTS The present study described the identification of two linear B-cell epitopes in ARV σB throug...

Journal: :The Japanese Journal of Ergonomics 2019

Journal: :Journal of biomolecular NMR 2001
G Kontaxis A Bax

A simple spectral editing procedure is described that generates separate subspectra for the methyl 13C-[1H3] multiplet components of 1H-13C HSQC spectra. The editing procedure relies on co-addition of in-phase and antiphase spectra and yields 1H-coupled constant-time HSQC subspectra for the methyl region that have the simplicity of the regular decoupled CT-HSQC spectrum. Resulting spectra permi...

2016
Zian Jin Tao Sun Xueshan Xia Qiujiang Wei Yuzhu Song Qinqin Han Qiang Chen Juan Hu Jinyang Zhang

BACKGROUND Herpes B virus (BV) is a zoonotic disease caused by double-stranded enveloped DNA virus with cercopithecidae as its natural host. The mortality rate of infected people could be up to 70% with fatal encephalitis and encephalomyelitis. Up to now, there are no effective treatments for BV infection. Among the various proteins encoded by monkey B virus, gD, a conserved structural protein,...

2015
Jeffrey R Kugelman Mariano Sanchez-Lockhart Kristian G Andersen Stephen Gire Daniel J Park Rachel Sealfon Aaron E Lin Shirlee Wohl Pardis C Sabeti Jens H Kuhn Gustavo F Palacios

Until recently, Ebola virus (EBOV) was a rarely encountered human pathogen that caused disease among small populations with extraordinarily high lethality. At the end of 2013, EBOV initiated an unprecedented disease outbreak in West Africa that is still ongoing and has already caused thousands of deaths. Recent studies revealed the genomic changes this particular EBOV variant undergoes over tim...

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