This study aims to elucidate the mechanism behind the potent weight loss induced by dual amylin and calcitonin receptor agonists (DACRA) through comparison of the novel DACRA KBP-088 with the amylinomimetic davalintide with regard to in vitro receptor pharmacology and in vivo efficacy on food intake and body weight. KBP-088 and davalintide were tested for their ability to activate the amylin an...

Unbundling presumptions of DSL standards groups are reviewed and contrasted with their respective counterparts in cable broadband access. This comparison evaluates the ultimate DSL network architecture under those presumptions as fiber penetrates further into the existing loop plant. The results of the evaluation then raise questions as to the future emphasis and focus of advanced DSL spectrum ...

Rofecoxib was originally submitted as an NDA in November 1998 and approved by the Agency in May 1999 for the relief of sign and symptom of osteo-arthritis (OA) and for the management of acute pain and dysmenorrhea. The current approved maximum dose was 25 mg daily for OA and 50 mg daily for acute pain. The purpose of this supplemental NDA submission was to provide evidence for label revision to...

In the present study, we compared two strains of serotypes 088:H25 and 0145:H45 with an enteropathogenic Escherichia coli (EPEC) adherence factor-positive (EAF+) strain of the classic enteropathogenic E. coli serotype 0111ab:H2 for their association with HeLa cells and with biopsies of human duodenal mucosa. Both strains not belonging to the classic EPEC serotype showed virulence properties sim...

Copyright: © 2016 Ali MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. *Corresponding author: Ahmed Ibrahim, Faculty of Veterinary Medicine, Assiut University, Assiut, Postal Code: 70155, Egypt, Tel:...

Lingling Wang 1 and Tsunemi Watanabe 1,2,* 1 School of Economics and Management, Kochi University of Technology, 2-22 Eikokuji-cho, Kochi City, Kochi 780-8515, Japan; [email protected] 2 Graduate School of Engineering, Kochi University of Technology, Miyanokuchi 185, Tosayamada-cho, Kami City, Kochi 782-0003, Japan * Correspondence: [email protected]; Tel.: +81-088-...