The UDP-3-O-(R-3-hydroxyacyl)-N-acetylglucosamine deacetylase LpxC is an essential enzyme of lipid A biosynthesis in Gram-negative bacteria and a promising antibiotic target. CHIR-090, the most potent LpxC inhibitor discovered to date, displays two-step time-dependent inhibition and kills a wide range of Gram-negative pathogens as effectively as ciprofloxacin or tobramycin. In this study, we re...

The deacetylation of UDP-3-O-[(R)-3-hydroxymyristoyl]-N-acetylglucosamine (UDP-3-O-acyl-GlcNAc) by LpxC is the committed reaction of lipid A biosynthesis. CHIR-090, a novel N-aroyl-l-threonine hydroxamic acid, is a potent, slow, tight-binding inhibitor of the LpxC deacetylase from the hyperthermophile Aquifex aeolicus, and it has excellent antibiotic activity against Pseudomonas aeruginosa and ...

The result of the paper can be deduced from already known results in [ST06] and [BHR05]. 1 MainAfter publishing the paper in ECCC, it has come to my attention that the result provenin the paper, lower bounds for adaptive linearity tests, can be deduced from alreadyknown results.As stated in the paper, the lower bound for non-adaptive linearity tests was provenby Samorodnitsk...

Leonardo Frois Hernandez Faculdade de Tecnologia de São Paulo, Pça. Cel. Fernando Prestes, 30, 01124-060 São Paulo – SP, Brasil Roberto da Rocha Lima Instituto de Física, Universidade de São Paulo, Rua do Matão, 187, Trav. R, 05508-090 São Paulo – SP, Brasil Alexsander Tressino de Carvalho, Nicole Raymonde Demarquette e Maria Lúcia Pereira da Silva* Escola Politécnica, Universidade de São Paulo...

Abstract Female mammals, including women, are exposed to endocrine disrupting chemicals (EDCs) on a daily basis. This is of concern because many EDCs inhibit ovarian follicle growth and steroidogenesis, processes that critical for maintaining female fertility. Our research focuses the effects known as phthalates Phthalates interest they ubiquitous synthetic used plasticizers stabilizers in myri...

A striking characteristic of cystic fibrosis (CF) is susceptibility to life-limiting bacterial infections of the respiratory tract (13, 26). Members of the Burkholderia cepacia complex are a particular cause of anxiety to CF individuals (8, 14, 23) since they display high resistance to antibiotics and biocides (3, 32), possibly linked to their relatively large ( 8to 9-Mbp) genomes (16). At pres...

Correspondence: Anastasios Dontas, Hellenic Association of Gerontology and Geriatrics, Athens, Greece 9 Afroditis Str., Athens, 105 58, Greece Tel 0030 210 3245 090 Fax 0030 210 3245 090 Email [email protected] Abstract: There are now several scientifi c studies that relate this traditional dietary pattern with the incidence of coronary heart disease, various types of cancer, and other diseases. T...

The present study examined the effects of two novel dopamine D3 receptor compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide], an antagonist, and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], a partial agonist, in two models of cocaine abuse in rhesus monkeys. To establish a dose range and time course of effec...