BACKGROUND The efficacy of TCN-032, a human monoclonal antibody targeting a conserved epitope on M2e, was explored in experimental human influenza. METHODS Healthy volunteers were inoculated with influenza A/Wisconsin/67/2005 (H3N2) and received a single dose of the study drug, TCN-032, or placebo 24 hours later. Subjects were monitored for symptoms, viral shedding, and safety, including cyto...

The sodium requirements, balance, excretion, patterns and composition of some pig tissues were studied in two feeding trials and a balance trial followed by an additional feeding period with terminal tissue composition analysis. The growth of pigs fed a corn-soybean meal diet without added salt was severely restricted. Results confirm that a sodium requirement of .09% of the diet is adequate an...

The CDK inhibitor SNS-032 had previously exerted promising anti-neuroblastoma activity via CDK7 and 9 inhibition. ABCB1 expression was identified as major determinant of SNS-032 resistance. Here, we investigated the role of ABCB1 in acquired SNS-032 resistance. In contrast to ABCB1-expressing UKF-NB-3 sub-lines resistant to other ABCB1 substrates, SNS-032-adapted UKF-NB-3 (UKF-NB-3rSNS- 032300n...

BACKGROUND Acute myeloid leukemia (AML) is a heterogeneous disorder with aberrant regulation of a variety of signal pathways. Therefore, simultaneous targeting of two or even more deregulated signal transduction pathways is needed to overcome drug resistance. Previously, it was reported that SNS-032, a selective cyclin-dependent kinase inhibitor, is an effective agent for treatment of AML; howe...

A one-year longitudinal study of changes in neuroticism and intelligence, as measured by a figural reasoning test, was conducted with 14 high school students who learned the Transcendental Meditation technique and six controls. Students who practiced Transcendental Meditation regularly (N = 7) decreased significantly in neuroticism (p <.OJ), while irregular meditators (N = 7) and nonmeditating ...

Consider the following symmetric encryption scheme (KG , E,D). KG chooses an AES key. E(k,m) := EAES (k,m)‖032. (032 stands for a string consisting of 32 zeros.) And the decryption D(k, c) does the following: Let c′‖p := c where p has length 32 bit and c′ is all but the last 32 bits of c. m := DAES (k, c′). If p = 032, then D(k, c) returns m. If p 6= 032 and kp = 0 (here kp is the p-th bit of t...

Inhibitors of cyclin-dependent kinases (Cdks) have been reported to have activities in chronic lymphocytic leukemia cells by inhibiting Cdk7 and Cdk9, which control transcription. Here we studied the novel Cdk inhibitor SNS-032, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. We hypothesized that transient inhibition of transcription by SNS-032 would decrea...

Inhibitors of cyclin-dependent kinases (Cdks) have been reported to have activities in chronic lymphocytic leukemia cells by inhibiting Cdk7 and Cdk9, which control transcription. Here we studied the novel Cdk inhibitor SNS-032, which exhibits potent and selective inhibitory activity against Cdk2, Cdk7, and Cdk9. We hypothesized that transient inhibition of transcription by SNS-032 would decrea...

Cantharidin isolated from Mylabris caraganae and other insects is used traditionally as an anti-cancer drug especially on hepatoma and leukaemia. Previously, we demonstrated that the novel synthetic cantharidin analogue CAN 032 possessed apoptotic activity on two human hepatoma cell lines Hep3B hepatocellular carcinoma and SK-Hep-1 liver adenocarcinoma. However, its underlying mechanistic actio...

The spores of several Bacillus species, including Bacillus pumilus SAFR-032 and B. safensis FO-36b, which were isolated from the spacecraft assembly facility at NASA's Jet Propulsion Laboratory, are unusually resistant to UV radiation and hydrogen peroxide. In order to identify candidate genes that might be associated with these resistances, the whole genome of B. pumilus SAFR-032, and the draf...