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تعداد نتایج: 522 فیلتر نتایج به سال:
Accumulating preclinical and clinical evidence data suggests that compounds that selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes may have therapeutic utility for the treatment of several neurological disorders. In the present study, the in vitro pharmacological properties of the novel cholinergic channel modulator ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)py...
Because modulation of cortical cholinergic neurotransmission has been hypothesized to represent a necessary mechanism mediating the beneficial cognitive effects of nicotine and nicotinic acetylcholine receptor (nAChR) subtype-selective agonists, we used choline-sensitive microelectrodes for the real-time measurement of ACh release in vivo, to characterize cholinergic transients evoked by nicoti...
ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride], a novel ligand at neuronal nicotinic acetylcholine receptors with reduced adverse effects and improved oral bioavailability relative to (-)-nicotine, was tested in a variety of cognitive tests in rats and monkeys. Administered acutely, ABT-089 only marginally improved the spatial discrimination water maze performance of s...
Received: July 15, 2005 Accepted for publication: November 16, 2005 From the Department of Surgery, Mackay Memorial Hospital Taitung Branch, Taiwan Address for reprints: Dr. Ruey-An Chiang, 1 Lane 303, Changsha Street, Taitung City, Taitung County 950, Taiwan, R.O.C. Department of Surgery, Mackay Memorial Hospital Taitung Branch, Taiwan Tel: (089) 310150 Fax: (089) 321240 E-mail: [email protected]....
Although nicotine mediates its effects through several nicotinic acetylcholine receptor (nAChR) subtypes, it remains to be determined which nAChR subtypes directly mediate heightened anxiety during withdrawal. Relative success in abstinence has been found with the nAChR partial agonist varenicline (Chantix; Pfizer, Groton, CT); however, treatment with this drug fails to alleviate anxiety in ind...
Although nicotine mediates its effects through several nicotinic acetylcholine receptor (nAChR) subtypes, it remains to be determined which nAChR subtypes directly mediate heightened anxiety during withdrawal. Relative success in abstinence has been found with the nAChR partial agonist varenicline (Chantix; Pfizer, Groton, CT ); however, treatment with this drug fails to alleviate anxiety in in...
We present results and first epoch parsec-scale images from a monitoring program on five γ–ray loud blazars selected on the basis of their total flux density variability. We observed 0048−097, 0235+164, 0954+658, 1510−089 and 1749+096 with the Very Long Baseline Array simultaneously at 8.4 GHz and 22 GHz. Comparison between our high quality images and previous results from the literature sugges...
Polarization offers a unique view in the physical processes of astrophysical jets. We report on optical circular polarization observations two famous blazars, namely 3C 279 and PKS 1510-089, at high linearly polarized states. This is first time 1510-089 observed polarization. While only upper limits can be extracted from our observing campaign, non-detection allows us to provide meaningful cons...
On the occasion of the thirty-first anniversary of the publication of The Multinational Corporation and the Law of Uneven Development by Hymer, the paper seeks to assess the relevance of Hymer’s prediction to our current understanding of the multinational company (MNC) and its role in world economic development. It argues that the largely ethnocentric type of MNC portrayed by Hymer is descripti...
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