In this study, our objective is to evaluate the potential of a novel Sorafenib derivative, named HLC-080, as a new anticancer agent for colon cancer. We firstly carried out MTT assay, colony formation assay, flow cytometry analysis and transwell invasion assay to determine effect of our compound HLC-080 on cell viability, anti-proliferation activity, cell cycle arrest and the intervention on ce...

BACKGROUND Treating symptoms and preventing exacerbations are key components of chronic obstructive pulmonary disease (COPD) long-term management. Recently, a more tailored treatment approach has been proposed, in particular for two well-established clinical phenotypes, frequent exacerbators and chronic bronchitis-dominant COPD. ELOM-080 has demonstrated clinical efficacy in treating symptoms a...

RY-080 (ethyl 8-ethynyl-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate) is an imidazobenzodiazepine with 40–50-fold higher affinity for the benzodiazepine binding site of α5rather than α1-, α2or α3-containing GABAA receptors. Previous data describing RY-080 as being convulsant suggests that inverse agonists selective for the α5 subtype may not be suitable for clin...

We present results from multi-epoch spectral analysis of XMM-Newton and Chandra observations of the mini broad absorption line (BAL) quasar PG 1115+080. This is one of the few X-ray detected mini-BAL quasars to date that is bright enough in the X-ray band, mostly due to large gravitationallensing magnifications, to allow in-depth spectral analysis. The present XMM-Newton observations of PG 1115...

This report documents the results of two follow-up workshops on the International Handbook of Labour Market Policy and Evaluation. The aim of these workshops was the exchange of experience among academics and practitioners in the evaluation of labour market policies. The Handbook project as well as the two workshops were supported from the beginning by DG V of the European Commission through th...

Address for correspondence: Prof. Luigi Macchia MD, PhD, Department and School of Allergology and Clinical Immunology, University of Bari – Aldo Moro, Piazza Giulio Cesare, Policlinico, 70124 Bari, Italy, phone: +39 080 5478817, fax: +39 080 5593688, e-mail: [email protected] Received: 30.01.2014, accepted: 29.04.2014 Long-term treatment of refractory severe chronic urticaria by omalizumab...

1 Central Animal Facility, Indian Institute of Science, Bangalore-560 012, India. 2 Anjuman Arts, Sciences & Commerce College, Bijapur-586101, India. 3 Research Centre, Electron Microscope Unit, # 5, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Kingdom of Saudi Arabia. 4 Centre for Sustainable Technologies, Indian Institute of Science, Bangalore-560 012, India. * Corre...

* Corresponding author. Maria De Angelis, Dipartimento di Protezione delle Piante e 13 Microbiologia Applicata, Facoltà di Scienze Biotecnologiche di Bari, Via G. Amendola 165/a, 14 70126 Bari, Italy. Phone: ++ 39 080 5442948; Fax: ++ 39 080 5442911; E-mail: 15 [email protected] 16 17 AC CE PT ED Copyright © 2007, American Society for Microbiology and/or the Listed Authors/Institutions. ...

AIM To examine the possible influence of the MHC class II antigens alleles in the formation of the multinucleate aggressive giant cell tumour of bone. METHODS HLA class II antigen alleles were investigated in eight white patients from north east England with confirmed diagnosis of giant cell tumour of bone. All had locally aggressive, immunophenotypically HLA-DR negative giant cell tumours. ...

New results about the simulation of Resistive Plate Chambers are reported; particular enphasys is put in the understanding of charge spectra in regions where deviations from the pure avalanche mode of operation can be present. Presented by M. Abbrescia at the International Conference on Advanced Technology and Particle Phyisics, Villa Olmo, Como, Italy, 5-9 October 1998 Submitted to Nucl. Phys....