Finding linear classifiers that maximize AUC scores is important in ranking research. This is naturally formulated as a 1-norm hard/soft margin optimization problem over pn pairs of p positive and n negative instances. However, directly solving the optimization problems is impractical since the problem size (pn) is quadratically larger than the given sample size (p + n). In this paper, we give ...

OBJECTIVE To evaluate the influence of surgical margin status on survival and site of recurrence in patients treated with hepatic resection for colorectal metastases. METHODS Using a multicenter database, 557 patients who underwent hepatic resection for colorectal metastases were identified. Demographics, operative data, pathologic margin status, site of recurrence (margin, other intrahepatic...

The cellular compositions of the inflammatory infiltrates in human colonic carcinoma in well-defined compartments have not been quantified previously. Morphometric analysis of this tissue revealed several relationships between the concentrations of different kinds of cells that may be an important first approach to understanding the nature of the host reaction in different groups of patients. P...

OBJECTIVE The aim of the study was to investigate the parameters affecting positive margin and the impact of positive margin on outcomes after breast-conserving therapy in patients with breast cancer. METHODS Characteristics and survival of 705 patients attempted breast-conserving therapy between January 1994 and December 2004 were retrospectively analyzed using χ(2) tests, the Kaplan-Meier m...

INTRODUCTION Among all prognostic factors, "margin status" is the only factor under clinician's control. Current guidelines describe histopathologic margin of >5 mm as "clear margin" and 1-5 mm as "close margin." Ambiguous description of positive margin in the published data resulted in comparison of microscopically "involved margin" and "close margin" together with "clear margin" in many publi...

OBJECTIVE To test the hypothesis that a safety margin may affect local tumor recurrence (LTR) in subsegmental chemoembolization. MATERIALS AND METHODS In 101 patients with 128 hepatocellular carcinoma (HCC) nodules (1-3 cm in size and ≤ 3 in number), cone-beam CT-assisted subsegmental lipiodol chemoembolization was performed. Immediately thereafter, a non-contrast thin-section CT image was ob...

Introductie 
 De Nederlandse Kennis- en Onderzoeksagenda Sociaal Werk (Hooghiemstra & Van Pelt, 2020) is tot stand gekomen op basis van een brede verkenning praktijkvragen onder sociaal werkers. Deze zijn door Raad kennis onderzoek geclusterd voorgelegd aan diverse groepen stakeholders. Het resultaat breed gedragen kennis- onderzoeksagenda geordend langs vier pijlers:
 Bevorderen ...

Radiologists have used margin characteristics based on routine visual analysis; however, the attenuation changes at the margin of the lesion on CT images have not been quantitatively assessed. We established a CT-based margin analysis method by comparing a target lesion with normal lung attenuation, drawing a slope to represent the attenuation changes. This approach was applied to patients with...